Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marília (UNIMAR), Marílla, São Paulo, Brazil.
Departments of, Department of, Biochemistry and Pharmacology, UNIMAR, Marílla, São Paulo, Brazil.
Clin Exp Dermatol. 2021 Jul;46(5):825-833. doi: 10.1111/ced.14584. Epub 2021 Mar 15.
Curcuma and its derivatives are associated with anti-inflammatory and antioxidant activities in the skin. They exhibit beneficial effects in wound healing and prevention of chronic ultraviolet B damage and may prevent facial redness such as rosacea and flushing. This review aims to provide an up-to-date and rigorous synthesis of studies that demonstrated the clinical efficacy of curcuminoids in the skin. We evaluated studies published in the MEDLINE-PubMed/PMC (National Library of Medicine) databases, and followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for this review. This search included papers published in the past 10 years in controlled clinical trials, double-blind and randomized controlled studies, and case studies. The search resulted in 12 studies published in the past 10 years. Curcuma species (Curcuma longa and Curcuma aeruginosa) and curcumin were found to produce various dermatological effects, including influencing antioxidant and anti-inflammatory processes in the production of hyaluronan, increasing skin moisture, and reducing axillary hair growth. Curcuma was also found to reduce thickness, erythema, pruritus, burning and pain in psoriasis lesions and to improve radiodermatitis lesions. Our review results show that Curcuma species may play a role in skin health management and may exhibit various dermatological effects, thus it could be a new therapeutic arsenal for dermatology professionals. Nevertheless, more clinical trials should be conducted with humans to establish the optimum delivery method and dosages for different dermatological conditions.
姜黄及其衍生物在皮肤中具有抗炎和抗氧化活性。它们在伤口愈合和预防慢性紫外线 B 损伤方面表现出有益的作用，并可能预防如酒渣鼻和潮红等面部发红。本综述旨在对证明姜黄素类化合物在皮肤中的临床疗效的研究进行最新和严格的综合分析。我们评估了在 MEDLINE-PubMed/PMC（美国国家医学图书馆）数据库中发表的研究，并遵循了系统评价和荟萃分析报告的首选条目，以进行本次综述。该搜索包括过去 10 年内发表的在对照临床试验、双盲和随机对照研究和案例研究中的论文。该搜索结果显示过去 10 年内发表了 12 项研究。姜黄属植物（姜黄和莪术）和姜黄素被发现产生各种皮肤效应，包括影响透明质酸的抗氧化和抗炎过程，增加皮肤水分，减少腋毛生长。姜黄还被发现可以减少银屑病病变的厚度、红斑、瘙痒、灼热和疼痛，并改善放射性皮炎病变。我们的综述结果表明，姜黄属植物可能在皮肤健康管理中发挥作用，并可能表现出各种皮肤效应，因此它可能成为皮肤科医生的新治疗武器。然而，应该进行更多的人体临床试验，以确定不同皮肤病况的最佳给药方法和剂量。
