a Medical School of Marília - UNIMAR - Marília , São Paulo , Brazil.
b Medical School of Marília - UNIMAR - Marília , São Paulo.
Crit Rev Food Sci Nutr. 2019;59(13):2136-2143. doi: 10.1080/10408398.2018.1456403. Epub 2018 Apr 12.
Crohn's Disease (CD) and Ulcerative Colitis (UC) result from an overreaction of the bowel to multifactorial stimuli leading to discomfort, pain, and it is associated with high morbidity and lethality. The medications commonly used are expensive and associated with multiple side effects. Curcuma longa exerts anti-inflammatory and antioxidant actions and has shown positive effects on CD and UC treatment, possibly due to the presence of curcuminoids. The objective of this review was to evaluate the role of curcuminoids in the treatment of IBD. A search for articles associating curcuminoids and CD and UC was performed using MEDLINE-PubMed. It has been found that curcumin can reduce oxidative stress and inhibit the migration of neutrophils and inducible nitric oxide synthase in the intestine. It may also improve micro and macroscopic lesions, prevent apoptosis of intestinal cells and also induce the restoration of the mitogen-activated protein kinase immune reaction. As the incidence of CD and UC is growing in many populations, there is an urgency to find an appropriate and accessible therapeutic approach to improve quality of life of patients. The use of curcumin is cheap, efficient and associated with no side effects, and may become an alternative to the IBD treatment.
克罗恩病（CD）和溃疡性结肠炎（UC）是由于肠道对多种刺激因素的过度反应导致的，这些反应会引起不适和疼痛，并且与高发病率和死亡率相关。常用的药物昂贵且副作用多。姜黄具有抗炎和抗氧化作用，并已显示出对 CD 和 UC 治疗的积极影响，这可能是由于存在姜黄素类。本综述的目的是评估姜黄素类在治疗 IBD 中的作用。使用 MEDLINE-PubMed 搜索与姜黄素类和 CD 及 UC 相关的文章。已经发现姜黄素可以减少氧化应激，抑制中性粒细胞和诱导型一氧化氮合酶在肠道中的迁移。它还可能改善微观和宏观病变，防止肠细胞凋亡，并诱导丝裂原激活蛋白激酶免疫反应的恢复。由于 CD 和 UC 在许多人群中的发病率不断上升，因此迫切需要找到一种合适且易于获得的治疗方法来改善患者的生活质量。使用姜黄便宜、高效且无副作用，可能成为治疗 IBD 的一种替代方法。
