The Autophagy Lab, Institute of Pathobiochemistry, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
J Cell Biochem. 2021 Jun;122(6):602-611. doi: 10.1002/jcb.29889. Epub 2021 Jan 31.
Recent advances in the yeast Saccharomyces cerevisiae and higher eukaryotes have been increasingly connecting lipid droplet (LD) dynamics to the regulation of autophagy. In this review we will discuss implications that connect LD de novo synthesis and LD mobilization to autophagy and how autophagy is regulated by these mechanisms. Elucidating these connections might pose a chance to further understand autophagy induction and membrane biogenesis for the growing autophagosome under different conditions. Increasing our understanding of these mechanisms might provide a chance to understand several conditions that might be related to LD dysregulation and, possibly, as a consequence of this, dysregulation of autophagy.
近年来，酿酒酵母和高等真核生物的研究进展越来越多地将脂滴（LD）动力学与自噬的调节联系起来。在这篇综述中，我们将讨论连接 LD 从头合成和 LD 动员与自噬的意义，以及这些机制如何调节自噬。阐明这些联系可能有助于进一步了解自噬诱导和膜生物发生，以便在不同条件下形成不断生长的自噬体。增加对这些机制的理解可能为理解与 LD 失调有关的几种情况提供机会，并可能因此导致自噬失调。
