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成年人从轻度 COVID-19 中康复后具有持久的细胞免疫。

Sustained cellular immunity in adults recovered from mild COVID-19.

机构信息

Hematology and Oncology, Medical Faculty, University of Augsburg, Augsburg, Germany.

Institute for Laboratory Medicine and Microbiology, Medical Faculty, University of Augsburg, Augsburg, Germany.

出版信息

Cytometry A. 2021 May;99(5):429-434. doi: 10.1002/cyto.a.24309. Epub 2021 Jan 31.

DOI:10.1002/cyto.a.24309
PMID:33522107
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8014675/
Abstract

Transient lymphocytopenia is frequently observed in acute phase of coronavirus disease 2019 (COVID-19). It remains a concern whether impairment of cellular immunity may be retained after COVID-19. Here, we demonstrate by extensive lymphocyte profiling in 44 adults after mild COVID-19 that cellular immunity is not fundamentally altered in convalescent patients. Except for increased activated CD8+ lymphocytes, total counts of B, T, and NK cells and their subsets did not differ significantly between patients after COVID-19 and healthy controls after a median of 27 days (range 13-45) suggesting no residual cellular immune deficiency after recovery from mild COVID-19.

摘要

一过性淋巴细胞减少症在 2019 年冠状病毒病（COVID-19）急性期经常观察到。人们仍然关注 COVID-19 后细胞免疫功能是否仍然受损。在这里，我们通过对 44 名轻度 COVID-19 后成年人的广泛淋巴细胞分析表明，在恢复期患者中，细胞免疫并未发生根本改变。除了增加的活化 CD8+淋巴细胞外，COVID-19 后患者和中位时间为 27 天（范围为 13-45）的健康对照者的 B、T 和 NK 细胞及其亚群的总计数没有显著差异，表明从轻度 COVID-19 恢复后没有残留的细胞免疫缺陷。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bdf/8014675/2556f7da59aa/CYTO-99-429-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bdf/8014675/0451a431e00f/CYTO-99-429-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bdf/8014675/2556f7da59aa/CYTO-99-429-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bdf/8014675/0451a431e00f/CYTO-99-429-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bdf/8014675/2556f7da59aa/CYTO-99-429-g002.jpg

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本文引用的文献

1
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JAMA. 2020 Jun 23;323(24):2518-2520. doi: 10.1001/jama.2020.8907.
2
Evaluation of commercial and automated SARS-CoV-2 IgG and IgA ELISAs using coronavirus disease (COVID-19) patient samples.利用冠状病毒病（COVID-19）患者样本评估商业和自动化 SARS-CoV-2 IgG 和 IgA ELISA 检测方法。
Euro Surveill. 2020 May;25(18). doi: 10.2807/1560-7917.ES.2020.25.18.2000603.
3
Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia.新型冠状病毒肺炎外周血淋巴细胞亚群特征变化。
循环淋巴细胞反映结直肠癌患者的局部免疫反应。
Diagnostics (Basel). 2022 Jun 7;12(6):1408. doi: 10.3390/diagnostics12061408.
4
An Update on Protective Effectiveness of Immune Responses After Recovery From COVID-19.关于从 COVID-19 中康复后免疫反应的保护效力的最新进展。
Front Immunol. 2022 May 20;13:884879. doi: 10.3389/fimmu.2022.884879. eCollection 2022.
5
Alterations of circulating lymphocyte subsets in patients with colorectal carcinoma.结直肠癌患者循环淋巴细胞亚群的改变。
Cancer Immunol Immunother. 2022 Aug;71(8):1937-1947. doi: 10.1007/s00262-021-03127-8. Epub 2021 Dec 20.
6
One Year after Mild COVID-19: The Majority of Patients Maintain Specific Immunity, But One in Four Still Suffer from Long-Term Symptoms.轻度新冠感染一年后：大多数患者保持特异性免疫，但四分之一的患者仍有长期症状。
J Clin Med. 2021 Jul 27;10(15):3305. doi: 10.3390/jcm10153305.
J Infect Dis. 2020 May 11;221(11):1762-1769. doi: 10.1093/infdis/jiaa150.
4
Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.中国武汉严重 COVID-19 患者的临床病程和结局：一项单中心、回顾性、观察性研究。
Lancet Respir Med. 2020 May;8(5):475-481. doi: 10.1016/S2213-2600(20)30079-5. Epub 2020 Feb 24.
5
Chemotherapy markedly reduces B cells but not T cells and NK cells in patients with cancer.化疗显著减少癌症患者的 B 细胞，但不减少 T 细胞和 NK 细胞。
Cancer Immunol Immunother. 2020 Jan;69(1):147-157. doi: 10.1007/s00262-019-02449-y. Epub 2020 Jan 3.
6
Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality.长期麻疹引起的免疫调节会增加儿童期传染病的总体死亡率。
Science. 2015 May 8;348(6235):694-9. doi: 10.1126/science.aaa3662. Epub 2015 May 7.
7
Measles virus-induced suppression of immune responses.麻疹病毒诱导的免疫反应抑制。
Immunol Rev. 2010 Jul;236:176-89. doi: 10.1111/j.1600-065X.2010.00925.x.
8
Significant changes of peripheral T lymphocyte subsets in patients with severe acute respiratory syndrome.严重急性呼吸综合征患者外周血T淋巴细胞亚群的显著变化。
J Infect Dis. 2004 Feb 15;189(4):648-51. doi: 10.1086/381535. Epub 2004 Feb 4.
9
Induction of lymphopenia and inhibition of T cell function during acute infection of swine with foot and mouth disease virus (FMDV).口蹄疫病毒（FMDV）急性感染猪期间淋巴细胞减少的诱导及T细胞功能的抑制
Vet Immunol Immunopathol. 2003 Mar 20;92(1-2):61-73. doi: 10.1016/s0165-2427(03)00004-7.
10
Peripheral blood lymphopenia and neutrophilia in children with severe respiratory syncytial virus disease.患有严重呼吸道合胞病毒疾病儿童的外周血淋巴细胞减少和中性粒细胞增多。
Pediatr Pulmonol. 2002 Aug;34(2):128-30. doi: 10.1002/ppul.10140.