O'Donnell Diarmuid R, Carrington David
Public Health Laboratory Service, St. Michael's Hill, Bristol, UK.
Pediatr Pulmonol. 2002 Aug;34(2):128-30. doi: 10.1002/ppul.10140.
It is not known why respiratory syncytial virus (RSV) is associated with prolonged sequelae in many children. Measles virus (also a paramyxovirus), acute stress in sepsis, and cardiac bypass all cause lymphopenia. Using a retrospective analysis of records of children in Bristol with RSV infections over 5 years, we found that children with RSV had lower lymphocyte counts than unstressed, stable children prior to cardiac surgery. Children who required intensive care had the lowest lymphocyte counts. Neutrophil counts were raised in RSV-infected children. These data may offer an insight into pathological mechanisms, and suggest new research avenues.
目前尚不清楚为何呼吸道合胞病毒（RSV）会与许多儿童的长期后遗症相关。麻疹病毒（也是一种副粘病毒）、败血症中的急性应激以及心脏搭桥手术都会导致淋巴细胞减少。通过对布里斯托尔5年来感染RSV的儿童记录进行回顾性分析，我们发现感染RSV的儿童在心脏手术前的淋巴细胞计数低于未受应激、状况稳定的儿童。需要重症监护的儿童淋巴细胞计数最低。RSV感染儿童的中性粒细胞计数升高。这些数据可能有助于深入了解病理机制，并为新的研究方向提供线索。
