Gao Liwei, Zhang Wenzhi, Yang Leiyan, Fan Hong, Olatunji Opeyemi Joshua
Department of Cardiovascular Medicine, Danyang Peoples Hospital of Jiangsu Province, Danyang, Jiangsu, China.
Innoscience Research Sdn Bhd, Selangor, Malaysia.
Arch Physiol Biochem. 2023 Feb;129(1):261-267. doi: 10.1080/13813455.2021.1876733. Epub 2021 Jan 31.
The present study investigated the effect of polyphenol-rich extract of (PPS) against pancreatic and hepatorenal dysfunction in high-fat diet (HFD)/streptozotocin (STZ)-induced diabetes. Diabetic rats were treated with PPS (100 and 400 mg/kg) and glibenclamide. The results revealed that diabetic rats displayed marked hyperglycaemia, hyperlipidaemia, hypoinsulinemia as well as alterations in serum renal and kidney function markers. Furthermore, diabetic rats showed significant increase in hepatorenal level of malonaldehyde as well as suppression of antioxidant enzyme activities. Whereas, diabetic rats that received PPS displayed marked attenuation in most of the aforementioned parameters compared to the untreated diabetic rats. Additionally, histological examination revealed restoration of histopathological alterations of the pancreas, liver, and kidney of PPS treated diabetic rats. In conclusion, the results demonstrated that PPS could decrease serum lipids and blood glucose level, enhance insulin level and hepatorenal antioxidant capacity, as well as ameliorate hepatorenal dysfunction in rats.
本研究调查了富含多酚的提取物（PPS）对高脂饮食（HFD）/链脲佐菌素（STZ）诱导的糖尿病大鼠胰腺及肝肾损伤的影响。给糖尿病大鼠分别灌胃PPS（100和400mg/kg）及格列本脲。结果显示，糖尿病大鼠表现出明显的高血糖、高血脂、低胰岛素血症，以及血清肾和肝功能标志物的改变。此外，糖尿病大鼠肝肾组织丙二醛水平显著升高，抗氧化酶活性受到抑制。然而，与未治疗的糖尿病大鼠相比，接受PPS治疗的糖尿病大鼠上述大多数参数均有明显改善。此外，组织学检查显示，PPS治疗的糖尿病大鼠胰腺、肝脏和肾脏的组织病理学改变得到恢复。总之，结果表明PPS可降低大鼠血脂和血糖水平，提高胰岛素水平及肝肾抗氧化能力，并改善肝肾损伤。
