Department of Family Medicine, Hsinchu MacKay Memorial Hospital, Hsinchu, Taiwan.
Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.
PLoS One. 2021 Feb 1;16(2):e0246378. doi: 10.1371/journal.pone.0246378. eCollection 2021.
To investigate the relationship between metabolically healthy obesity and cardiovascular disease risk in Taiwanese individuals.
Taiwanese individuals were recruited from a nationwide, representative community-based prospective cohort study and classified according to body mass index as follows: normal weight (18.5-23.9 kilogram (kg)/meter(m)2) and obesity/overweight (≥24 kg/m2). Participants without diabetes, hypertension, and hyperlipidemia and who did not meet the metabolic syndrome without waist circumference criteria were considered metabolically healthy. The study end points were cardiovascular disease morbidity and mortality. Multivariable adjusted hazard ratios and 95% confidence intervals were obtained from a Cox regression analysis.
Among 5 358 subjects (mean [standard deviation] age, 44.5 [15.3] years; women, 48.2%), 1 479 were metabolically healthy with normal weight and 491 were metabolically healthy with obesity. The prevalence of metabolically healthy obesity/overweight was 8.6% in the Taiwanese general population, which included individuals who were >20 years old, not pregnant, and did not have CVD (n = 5,719). In the median follow-up period of 13.7 years, 439 cardiovascular disease events occurred overall and 24 in the metabolically healthy obesity group. Compared with the reference group, the metabolically healthy obesity group had a significantly higher cardiovascular disease risk (adjusted hazard ratio: 1.74, 95% confidence interval: 1.02, 2.99).
Individuals with metabolically healthy obesity have a higher risk of cardiovascular disease and require aggressive body weight control for cardiovascular disease control.
探讨台湾个体中代谢健康型肥胖与心血管疾病风险的关系。
从一项全国性、具有代表性的社区前瞻性队列研究中招募台湾个体，并根据体重指数分为以下两组：正常体重（18.5-23.9 千克/米 2）和肥胖/超重（≥24 千克/米 2）。无糖尿病、高血压和高血脂且不符合腰围标准的代谢综合征患者被认为是代谢健康的。研究终点为心血管疾病发病率和死亡率。多变量调整后的风险比和 95%置信区间通过 Cox 回归分析获得。
在 5358 名受试者（平均[标准差]年龄，44.5[15.3]岁；女性，48.2%）中，1479 名代谢健康且体重正常，491 名代谢健康且肥胖。在台湾一般人群中，代谢健康型肥胖/超重的患病率为 8.6%，包括年龄＞20 岁、非妊娠和无 CVD（n=5719）的个体。在中位随访 13.7 年期间，共有 439 例心血管疾病事件发生，其中代谢健康型肥胖组发生 24 例。与参考组相比，代谢健康型肥胖组心血管疾病风险显著更高（调整后的风险比：1.74，95%置信区间：1.02，2.99）。
代谢健康型肥胖的个体患心血管疾病的风险较高，需要积极控制体重以控制心血管疾病。
