Nilsson Peter M, Korduner Johan, Magnusson Martin
Department of Clinical Sciences, Department of Internal Medicine, Skåne University Hospital, Lund University, Jan Waldenströms gata 15, 5th floor, S-20502, Malmö, Sweden.
Department of Cardiology, Clinical Research Centre (CRC), Jan Waldenströms gata 35, S-20502, Malmö, Sweden.
Curr Hypertens Rep. 2020 Feb 17;22(2):18. doi: 10.1007/s11906-020-1027-7.
To discuss new findings on the heterogeneity of obesity and associated risks.
Obesity is a public health problem of immense importance on a global scale. However, epidemiological findings and clinical studies have revealed that obesity is a heterogeneous phenotype and that not all obese subjects run the same risk for complications. Current research has tried to describe so-called metabolically healthy obesity (MHO), defined by lack of risk factors included in the metabolic syndrome. These subjects will not escape long-term complications, but mortality risk is not increased. However, a new definition of MHO has recently been proposed, based on the lack of hospitalisation for somatic disease for decades in middle life. MHO subjects defined in this way are characterised by being "fat and fit" and also run a lower risk of long-term complications. If MHO could be better understood, this could contribute to a more diverse clinical approach to obesity based on personalised medicine.
探讨肥胖异质性及相关风险的新发现。
肥胖是全球范围内极为重要的公共卫生问题。然而，流行病学研究结果和临床研究表明，肥胖是一种异质性表型，并非所有肥胖个体发生并发症的风险都相同。当前研究试图描述所谓的代谢健康型肥胖（MHO），其定义为不存在代谢综合征所包含的风险因素。这些个体虽无法避免长期并发症，但死亡风险并未增加。然而，最近基于中年时期数十年未因躯体疾病住院提出了MHO的新定义。以此方式定义的MHO个体具有“肥胖但健康”的特征，且长期并发症风险较低。若能更好地理解MHO，这可能有助于基于个性化医疗对肥胖采取更多样化的临床治疗方法。
