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职业性鼻炎

Occupational rhinitis.

作者信息

Kotz Sebastian, Pechtold Lisa, Jörres Rudolf A, Nowak Dennis, Chaker Adam M

机构信息

Department of Otolaryngology - Head and Neck Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Center of Allergy and Environment (ZAUM) of the Technical University of Munich (TUM) and the Helmholtz Zentrum München (HMGU), and.

出版信息

Allergol Select. 2021 Jan 22;5:51-56. doi: 10.5414/ALX02165E. eCollection 2021.

Abstract

Occupational rhinitis (OR) has so far received little attention even though it shares common pathophysiological features and trigger factors and is closely associated with occupational asthma (OA). Work-related exposure to certain substances, such as animal dander, is considered to be the main factor for the development of OR. The new EAACI definition of OR stresses the causal relationship between workplace exposure and onset of rhinitis symptoms as opposed to previous definitions that mainly focused on a temporal relationship between workplace exposure and occurrence of nasal symptoms. Also, it has been suggested to use the term "work-related rhinitis" for classifying the different forms of rhinitis associated with the workplace. These forms can be subdivided into allergic or non-allergic OR, which is due to causes and conditions related to a particular work environment, as well as work-exacerbated rhinitis, which is defined as a pre-existing rhinitis exacerbated by exposure at the workplace. Even though taking a detailed patient history is especially important when it comes to diagnosing OR, the gold standard for confirming the diagnosis is nasal provocation testing. Best possible symptomatic relief and prevention of development of OA constitute the main therapeutic objectives in OR. Treatment options consist of total avoidance of trigger substances (main goal), reduction of exposure to certain substances, and pharmacotherapy. Furthermore, it is important to note that allergic OR is an occupational disease in Germany (Berufskrankheit No 4301) and needs to be reported to health authorities.

摘要

职业性鼻炎(OR)尽管与职业性哮喘(OA)具有共同的病理生理特征和触发因素,且两者密切相关,但迄今为止仍未受到足够关注。与工作相关的某些物质暴露,如动物皮屑,被认为是职业性鼻炎发病的主要因素。欧洲变态反应和临床免疫学会(EAACI)对职业性鼻炎的新定义强调了工作场所暴露与鼻炎症状发作之间的因果关系,这与以往主要关注工作场所暴露与鼻部症状出现之间时间关系的定义不同。此外,有人建议使用“与工作相关的鼻炎”这一术语来对与工作场所有关的不同形式的鼻炎进行分类。这些形式可细分为过敏性或非过敏性职业性鼻炎,后者是由特定工作环境相关的原因和条件引起的,还有工作加重性鼻炎,其定义为已有的鼻炎因工作场所暴露而加重。尽管在诊断职业性鼻炎时详细询问患者病史尤为重要,但确诊的金标准是鼻激发试验。实现最佳的症状缓解和预防职业性哮喘的发展是职业性鼻炎的主要治疗目标。治疗选择包括完全避免触发物质(主要目标)、减少对某些物质的暴露以及药物治疗。此外,需要注意的是,在德国,过敏性职业性鼻炎属于职业病(职业病编号4301),需要向卫生当局报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caff/7841416/a8e34e2b90b4/allergologieselect-5-051-01.jpg

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