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发育性语言障碍成人的程序性记忆学习缺陷和陈述性记忆巩固缺陷

Deficits of Learning in Procedural Memory and Consolidation in Declarative Memory in Adults With Developmental Language Disorder.

作者信息

Earle F Sayako, Ullman Michael T

机构信息

Department of Communication Sciences and Disorders, University of Delaware, Newark.

Department of Neuroscience, Georgetown University, Washington, DC.

出版信息

J Speech Lang Hear Res. 2021 Feb 17;64(2):531-541. doi: 10.1044/2020_JSLHR-20-00292. Epub 2021 Feb 1.

Abstract

Purpose This study examined procedural and declarative learning and consolidation abilities in adults with developmental language disorder (DLD) relative to their typical language (TD) peers. Method A total of 100 young adults (age 18-24 years) with ( = 21) and without ( = 79) DLD participated across two sites. Performance measures on a recognition memory task and a serial reaction time task were used to assess declarative and procedural memory, respectively. Performance was measured shortly after learning (8 a.m.) and again after a 12-hr, overnight delay (8 a.m.). Results Linear mixed-effects modeling was used to examine the effects of time and group membership on task performance. For the serial reaction time task, there were significant effects of group (TD > DLD) and time (Day 1 > Day 2), but no interaction between them. For the recognition memory task, there was a significant interaction between group and time, driven by overnight gains in the TD group, combined with stable performance across days by those with DLD. Conclusions In procedural memory, adults with DLD demonstrate a learning deficit relative to adults without DLD, but appear to have comparable retention of learned information. In declarative memory, adults with DLD demonstrate a deficit in the overnight enhancement of memory retrieval, despite typical-like learning exhibited when tested shortly after encoding. Supplemental Material https://doi.org/10.23641/asha.13626485.

摘要

目的 本研究考察了发育性语言障碍(DLD)成人相对于其典型语言(TD)同龄人在程序性和陈述性学习及巩固能力方面的情况。方法 共有100名18 - 24岁的年轻人参与了两个地点的研究,其中21名患有DLD,79名未患DLD。分别使用识别记忆任务和序列反应时任务的表现指标来评估陈述性记忆和程序性记忆。在学习后不久(上午8点)以及经过12小时的夜间延迟后(上午8点)测量表现。结果 使用线性混合效应模型来检验时间和组别对任务表现的影响。对于序列反应时任务,存在显著的组别效应(TD > DLD)和时间效应(第1天 > 第2天),但它们之间没有交互作用。对于识别记忆任务,组别和时间之间存在显著的交互作用,这是由TD组夜间的记忆提升以及DLD患者各天表现稳定所驱动的。结论 在程序性记忆方面,患有DLD的成年人相对于未患DLD的成年人表现出学习缺陷,但在所学信息的保持方面似乎相当。在陈述性记忆方面,患有DLD的成年人在记忆提取的夜间增强方面存在缺陷,尽管在编码后不久测试时表现出类似正常的学习情况。补充材料 https://doi.org/10.23641/asha.13626485

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