Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
Arch Physiol Biochem. 2023 Dec;129(4):870-878. doi: 10.1080/13813455.2021.1877308. Epub 2021 Feb 1.
This study was conducted to evaluate the anti-diabetic and antioxidant effects of hydroalcoholic pomegranate peel extract (APE) in alloxan-induced diabetes rat models. We divided 60 rats into the following six equal groups ( = 10): Healthy control; diabetic control (100 mg/kg alloxan); sham + glibenclamide (10 mg/kg); diabetic + glibenclamide (10 mg/kg); sham + APE (200 mg/kg) and diabetic + APE (200 mg/kg). After 8 weeks, kidneys were taken out for biochemical and molecular studies. Following APE treatment, biochemical parameters including malondialdehyde (MDA), and glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD) significantly induced in the treated group as compared with the control group ( < 0.05). Also, gene expression of (3-fold), (2.6-fold), and (1.5-fold) were increased as compared to controls ( < 0.05). Overall, our results indicated that pomegranate can be used as an antioxidant agent to reduce complications from diseases associated with oxidative stress.
本研究旨在评估石榴皮水醇提取物（APE）在链脲佐菌素诱导的糖尿病大鼠模型中的抗糖尿病和抗氧化作用。我们将 60 只大鼠分为以下六组（每组 10 只）：健康对照组；糖尿病对照组（100mg/kg 链脲佐菌素）；假手术+格列本脲（10mg/kg）；糖尿病+格列本脲（10mg/kg）；假手术+APE（200mg/kg）和糖尿病+APE（200mg/kg）。8 周后，取出肾脏进行生化和分子研究。在 APE 治疗后，与对照组相比，治疗组的生化参数如丙二醛（MDA）和谷胱甘肽（GSH）、谷胱甘肽过氧化物酶（GPx）、过氧化氢酶（CAT）、超氧化物歧化酶（SOD）显著升高（<0.05）。此外，与对照组相比，（3 倍）、（2.6 倍）和（1.5 倍）的基因表达也增加（<0.05）。总的来说，我们的结果表明，石榴可以作为抗氧化剂，减少与氧化应激相关疾病的并发症。
