Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, 59000 Lille, France.
Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, 59000 Lille, France.
Biochim Biophys Acta Mol Basis Dis. 2021 May 1;1867(5):166097. doi: 10.1016/j.bbadis.2021.166097. Epub 2021 Jan 29.
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and transcriptional modulators with crucial functions in hepatic and whole-body energy homeostasis. Besides their well-documented roles in lipid and glucose metabolism, emerging evidence also implicate PPARs in the control of other processes such as inflammatory responses. Recent technological advances, such as single-cell RNA sequencing, have allowed to unravel an unexpected complexity in the regulation of PPAR expression, activity and downstream signaling. Here we provide an overview of the latest advances in the study of PPARs in liver physiology, with a specific focus on formerly neglected aspects of PPAR regulation, such as tissular zonation, cellular heterogeneity, circadian rhythms, sexual dimorphism and species-specific features.
过氧化物酶体增殖物激活受体 (PPARs) 是核受体和转录调节剂，在肝脏和全身能量稳态中具有关键作用。除了它们在脂质和葡萄糖代谢中的作用已得到充分证实外，新出现的证据还表明 PPARs 参与了其他过程的控制，如炎症反应。最近的技术进步，如单细胞 RNA 测序，使人们能够揭示 PPAR 表达、活性和下游信号转导调节的意外复杂性。本文概述了肝脏生理学中 PPAR 研究的最新进展，特别关注了以前被忽视的 PPAR 调节方面，如组织分区、细胞异质性、昼夜节律、性别二态性和种间特异性。
