微小奇迹：对无瘢痕伤口愈合的纳米管理的见解

Petite miracles: insight into the nano-management of scarless wound healing.

作者信息

Pan Bei Ho, Zhang Qiang, Lam Chun Hei, Yuen Ho Yin, Kuang Shifeng, Zhao Xin

机构信息

Department of Biomedical Engineering, the Hong Kong Polytechnic University, Hung Hom, Hong Kong, China.

Department of Plastic Surgery, Guangdong Provincial People's Hospital, Guangzhou 510080, China.

出版信息

Drug Discov Today. 2022 Mar;27(3):857-865. doi: 10.1016/j.drudis.2021.01.025. Epub 2021 Jan 29.

DOI:10.1016/j.drudis.2021.01.025

PMID:33524602

Abstract

Scars affect millions of patients worldwide, yet their treatment efficacy and options clinically remain limited. In recent years, increased understanding of scar formation pathways leading to developments in nanotechnology have opened many opportunities for scar detection, prevention, and treatment due to the nanoscale features and therapeutic delivery capabilities of such technologies. Led by nanoparticles (NPs) and nanofibers, these novel strategies can aid in reducing scar contracture, improving wound-healing efficacy, and advancing progress towards scarless wound healing.

摘要

疤痕影响着全球数百万患者，然而其临床治疗效果和选择仍然有限。近年来，随着对疤痕形成途径的认识不断加深，纳米技术得到了发展，由于这些技术的纳米级特征和治疗递送能力，为疤痕的检测、预防和治疗带来了许多机会。以纳米颗粒（NPs）和纳米纤维为首，这些新策略有助于减少疤痕挛缩，提高伤口愈合效果，并推动实现无疤痕伤口愈合的进展。