Department of Oral and Maxillofacial Surgery, University Hospital of Giessen and Marburg, UKGM GmbH, Campus Marburg, Faculty of Medicine, Philipps-University of Marburg, Marburg, Germany.
Department of Plastic, Reconstructive, Aesthetic and Maxillofacial Surgery, Henri Mondor University Hospital, AP-HP, Faculty of Medicine, University Paris-Est Créteil Val de Marne (Paris XII), Créteil, France.
J Stomatol Oral Maxillofac Surg. 2022 Feb;123(1):64-73. doi: 10.1016/j.jormas.2021.01.012. Epub 2021 Jan 30.
To execute a review answering the following question: "Among novel coronavirus disease (COVID19) patients, what are craniomaxillofacial (CMF) manifestations?" based on the RAMESES and the German Association of Scientific Medical Societies (AWMF)'s S2e guidelines.
We performed a realist synthesis and meta-narrative review extracting data in English, French, German and Thai from PubMed/Medline, Embase, Biomed Central, Cochrane Library, and Thai Journals Online, until 1 January 2021. The primary outcome variable was CMF manifestations grouped into 5 categories: (1) mouth and throat, (2) nose, paranasal sinus, and skull base (3) ocular/orbital and periorbital tissue, (4) ear, and (5) craniofacial skin. Appropriate statistics was computed.
Thirty-seven original articles meeting the inclusion criteria were analysed; all were in English and indexed in PubMed/Medline. Hand searches of their references yielded a total of 101 articles for the review. Most data were in low level of evidence and focused on smell and taste disturbances and non-specific orofacial lesions. Iatrogenic complications may occur in this body region. Conservative measures remained effective and were usually enough for patient care.
Because SARS-CoV-2 infection is new and becomes the stringent worldwide pandemic within a short time period, most of the data on CMF symptoms are of low level evidence. Apart from taste and smell dysfunctions, non-specific CMF lesions can be found and treated conservatively. Treatment complications are possible. Dentists and CMF surgeons are privileged to examine the orofacial region and work closely with colleagues in other specialities to combat this pandemic.
根据 RAMESES 和德国科学医学协会（AWMF）的 S2e 指南，执行一项综述，回答以下问题：“在新型冠状病毒病（COVID-19）患者中，颅面（CMF）表现如何？”。
我们进行了一项真实主义综合和元叙述性综述，从 PubMed/Medline、Embase、Biomed Central、Cochrane Library 和泰国在线期刊中提取英语、法语、德语和泰语数据，截至 2021 年 1 月 1 日。主要结局变量是 CMF 表现，分为 5 类：（1）口腔和咽喉，（2）鼻、副鼻窦和颅底，（3）眼部/眼眶和眶周组织，（4）耳，和（5）颅面皮肤。计算了适当的统计数据。
分析了符合纳入标准的 37 篇原始文章；均为英文，并在 PubMed/Medline 中索引。对其参考文献的手工检索共获得 101 篇综述文章。大多数数据的证据水平较低，主要集中在嗅觉和味觉障碍以及非特异性口腔病变上。该身体区域可能发生医源性并发症。保守治疗仍然有效，通常足以满足患者的护理需求。
由于 SARS-CoV-2 感染是新的，并且在短时间内成为严格的全球大流行，因此大多数关于 CMF 症状的证据水平较低。除了味觉和嗅觉功能障碍外，还可以发现非特异性 CMF 病变，并进行保守治疗。可能存在治疗并发症。牙医和 CMF 外科医生有特权检查口腔区域，并与其他专业的同事密切合作，以对抗这一大流行。
