Moja E A, Lucini V, Benedetti F, Lucca A
Chair of Medical Psychology, University of Milan, Padiglione L.I.T.A., Ospedale L. Sacco.
Life Sci. 1996 May 24;58(26):2389-95. doi: 10.1016/0024-3205(96)00242-1.
After an overnight fast, 5 male healthy subjects ingested increasing amounts of a solution containing a fixed proportion of seven essential amino acids (L-isoleucine, 13.3%; L-leucine, 21.0%; L-lysine, 15.2%; L-methionine, 21.0%; L-threonine, 9.5%; L-tryptophan, 4.8% and L-valine, 15.2%) and lacking phenylalanine and tyrosine. The solutions caused a rapid fall in plasma phenylalanine and tyrosine which was proportional to the total amount of amino acids ingested. Following the highest dose administered (31.5 g) plasma phenylalanine and tyrosine fell to a minimum of, respectively, 12.7% and 29.8% the initial levels and remained markedly reduced at 6 hours after treatment. The decrease of tyrosine and phenylalanine levels was associated with a decrease of systolic and diastolic arterial pressure.
在禁食过夜后，5名健康男性受试者摄入了含有固定比例七种必需氨基酸（L-异亮氨酸，13.3%；L-亮氨酸，21.0%；L-赖氨酸，15.2%；L-蛋氨酸，21.0%；L-苏氨酸，9.5%；L-色氨酸，4.8%和L-缬氨酸，15.2%）且不含苯丙氨酸和酪氨酸的溶液。这些溶液导致血浆苯丙氨酸和酪氨酸迅速下降，下降幅度与摄入的氨基酸总量成正比。在给予最高剂量（31.5克）后，血浆苯丙氨酸和酪氨酸分别降至初始水平的最低值，即12.7%和29.8%，并且在治疗后6小时仍显著降低。酪氨酸和苯丙氨酸水平的降低与收缩压和舒张压的降低相关。
