Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China; Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China; Department of Environmental and Occupational Health, Public Health Ontario, Toronto, ON, Canada; Populations and Public Health Research Program, ICES, Toronto, ON, Canada.
Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China.
Sci Total Environ. 2021 Jun 1;771:144583. doi: 10.1016/j.scitotenv.2020.144583. Epub 2021 Jan 18.
Environmental factors such as air pollution may contribute to the development of childhood obesity. However, current epidemiological evidence is limited and inconsistent.
We investigated the associations between long-term air pollution exposure and obesity in a large population of Chinese children and adolescents.
A total of 44,718 children and adolescents (50.5% boys) aged 7 to 18 years were recruited from seven provinces/municipalities in China. Body mass index (BMI), waist circumference, waist-to-height ratio (WHtR) and the prevalence of general and central obesity were measured. Satellite-based spatial-temporal models were used to estimate ambient concentrations of particulate matter with aerodynamic diameter < 1.0 μm (PM), <2.5 μm (PM), <10.0 μm (PM) and nitrogen dioxide (NO). We used mixed-effects linear and logistic regression models to examine the associations between air pollution exposure and body weight measures.
Exposure to PM, PM, PM and NO was associated with increased BMI Z-score, waist circumference and WHtR, and higher prevalence of both general and central obesity. Generally, stronger associations were observed for particles, especially PM and PM, than for NO. Also, the associations of particles were generally more stable in two-pollutant models. Overall, the associations were more pronounced in boys than in girls except for general obesity.
Long-term exposure to air pollution was associated with increased body weight and higher prevalence of obesity in children and adolescents, suggesting potential obesogenic effects of air pollution.
环境因素，如空气污染，可能导致儿童肥胖的发展。然而，目前的流行病学证据是有限的，而且不一致。
我们调查了在中国一个庞大的儿童和青少年人群中，长期空气污染暴露与肥胖之间的关联。
共招募了来自中国七个省/直辖市的 44718 名 7 至 18 岁的儿童和青少年（50.5%为男孩）。测量了体重指数（BMI）、腰围、腰高比（WHtR）以及全身肥胖和中心性肥胖的患病率。使用基于卫星的时空模型来估计空气动力学直径<1.0μm（PM）、<2.5μm（PM）、<10.0μm（PM）和二氧化氮（NO）的环境浓度。我们使用混合效应线性和逻辑回归模型来检验空气污染暴露与体重指标之间的关联。
暴露于 PM、PM、PM 和 NO 与 BMI Z 评分、腰围和 WHtR 的增加以及全身和中心性肥胖的患病率升高有关。一般来说，与 NO 相比，颗粒物质，特别是 PM 和 PM，与这些结果的关联更强。此外，在双污染物模型中，颗粒物质的关联通常更稳定。总的来说，这些关联在男孩中比在女孩中更为明显，除了全身肥胖。
长期暴露于空气污染与儿童和青少年体重增加和肥胖患病率升高有关，表明空气污染可能具有致肥胖作用。
