Zielińska-Błajet Mariola, Najdek Joanna
Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland.
Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany.
Materials (Basel). 2021 Jan 28;14(3):600. doi: 10.3390/ma14030600.
An efficient approach to the synthesis of chiral selenoureas consisting of alkaloid scaffolds was described. The new selenoureas were assessed as bifunctional organocatalysts in the asymmetric Michael addition reactions under mild conditions. The best results were obtained for selenoureas bearing the 4-fluorophenyl group. These catalysts promoted the reactions with enantioselectivities of up to 96% ee. Additionally, the catalytic performance of the thiourea and selenourea counterpart was compared.
描述了一种合成由生物碱骨架组成的手性硒脲的有效方法。在温和条件下，将新型硒脲作为双功能有机催化剂用于不对称迈克尔加成反应中进行评估。对于带有4-氟苯基的硒脲，获得了最佳结果。这些催化剂促进反应的对映选择性高达96%ee。此外，还比较了硫脲和硒脲对应物的催化性能。
