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对高胆固醇血症大鼠的株特异性作用及潜在机制。

Strain-Specific Effects of on Hypercholesterolemic Rats and Potential Mechanisms.

机构信息

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, China.

出版信息

Int J Mol Sci. 2021 Jan 28;22(3):1305. doi: 10.3390/ijms22031305.

DOI:10.3390/ijms22031305
PMID:33525627
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7866116/
Abstract

Hypercholesterolemia is an independent risk factor of cardiovascular disease, which is among the major causes of death worldwide. The aim of this study was to explore whether Bifidobacterium longum strains exerted intra-species differences in cholesterol-lowering effects in hypercholesterolemic rats and to investigate the potential mechanisms. SD rats underwent gavage with each strain (CCFM 1077, I3, J3 and B3) daily for 28 days. CCFM 1077 exerted the most potent cholesterol-lowering effect, followed by I3 and B3, whereas B3 had no effect in alleviating hypercholesterolemia. Divergent alleviation of different strains on hypercholesterolemia can be attributed to the differences in bile salt deconjugation ability and cholesterol assimilation ability in vitro. By 16S rRNA metagenomics analysis, the relative abundance of beneficial genus increased in the CCFM 1077 treatment group. The expression of key genes involved in cholesterol metabolism were also altered after the CCFM 1077 treatment. In conclusion, exhibits strain-specific effects in the alleviation of hypercholesterolemia, mainly due to differences in bacterial characteristics, bile salt deconjugation ability, cholesterol assimilation ability, expressions of key genes involved in cholesterol metabolism and alterations of gut microbiota.

摘要

高胆固醇血症是心血管疾病的独立危险因素，也是全球主要死亡原因之一。本研究旨在探讨长双歧杆菌菌株在降胆固醇作用方面是否存在种内差异，并探讨其潜在机制。SD 大鼠每天用每种菌株（CCFM 1077、I3、J3 和 B3）灌胃 28 天。CCFM 1077 表现出最强的降胆固醇作用，其次是 I3 和 B3，而 B3 对缓解高胆固醇血症没有作用。不同菌株对高胆固醇血症的缓解作用不同，这归因于体外胆汁盐去结合能力和胆固醇同化能力的差异。通过 16S rRNA 宏基因组分析，CCFM 1077 处理组有益属的相对丰度增加。胆固醇代谢关键基因的表达也在 CCFM 1077 处理后发生改变。总之，在缓解高胆固醇血症方面，表现出菌株特异性效应，主要归因于细菌特性、胆汁盐去结合能力、胆固醇同化能力、胆固醇代谢关键基因的表达以及肠道微生物群的改变。

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