Liu He, Pan Li-Long, Lv Siting, Yang Qin, Zhang Hao, Chen Wei, Lv Zhuwu, Sun Jia
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
School of Food Science and Technology, Jiangnan University, Wuxi, China.
Front Physiol. 2019 Aug 6;10:1015. doi: 10.3389/fphys.2019.01015. eCollection 2019.
Clinical gestational diabetes mellitus (GDM) is frequently associated with hyperlipidemia comorbidity. Altered human gut microbiome has been linked to GDM and hyperlipidemia, respectively but not the comorbid condition. We hypothesize that the occurrence of hyperlipidemia with GDM may be characterized by distinguishable gut microbiome and blood metabolomic patterns. We presented comprehensive microbiomic coupled with lipidomics analyses to characterize gut microbiota and lipometabolism of plasma samples in women with GDM only, hyperlipidemia only and those with diabetes plus hyperlipidemia, and to explore association of the gut microbiota composition with blood lipid profiles and clinical parameters of gestational diabetes with or without commodity. We found that the relative abundance of bacterial taxa , , , , and was significantly higher in diabetes plus hyperlipidemia cohorts. Moreover, several bacteria were correlated with fasting plasma glucose and blood lipid levels of the participants with GDM and hyperlipidemia. The altered plasma lipidome in subjects with diabetes plus hyperlipidemia suggested that characteristic blood lipid profiles were associated with the pathogenesis of gestational diabetes plus hyperlipidemia. Collectively, this study provides insights on changes in fecal microbiota and plasma lipidome to predict and characterize the development of gestational diabetes with lipid metabolic abnormality.
临床妊娠糖尿病（GDM）常与高脂血症合并存在。人体肠道微生物群的改变分别与GDM和高脂血症有关，但与合并症无关。我们假设，GDM合并高脂血症的发生可能具有可区分的肠道微生物群和血液代谢组学特征。我们进行了全面的微生物组学与脂质组学分析，以表征仅患有GDM、仅患有高脂血症以及患有糖尿病合并高脂血症的女性血浆样本的肠道微生物群和脂质代谢，并探讨肠道微生物群组成与血脂谱以及妊娠糖尿病伴或不伴合并症临床参数之间的关联。我们发现，在糖尿病合并高脂血症队列中，细菌分类群 、 、 、 、 和 的相对丰度显著更高。此外，几种细菌与患有GDM和高脂血症参与者的空腹血糖和血脂水平相关。糖尿病合并高脂血症患者血浆脂质组的改变表明，特征性血脂谱与妊娠糖尿病合并高脂血症的发病机制有关。总体而言，本研究为粪便微生物群和血浆脂质组的变化提供了见解，以预测和表征伴有脂质代谢异常的妊娠糖尿病的发展。
