Tanosaki Sho, Tohyama Shugo, Kishino Yoshikazu, Fujita Jun, Fukuda Keiichi
Department of Cardiology, Keio University School of Medicine, Shinjuku, Tokyo, 160-8582, Japan.
Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Shinjuku, Tokyo, 160-8582, Japan.
Inflamm Regen. 2021 Feb 1;41(1):5. doi: 10.1186/s41232-021-00156-9.
Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling. While several protocols for differentiating somatic cells from PSCs exist, their use is limited by contamination of residual undifferentiated PSCs and immaturity of differentiated somatic cells.The metabolism of PSCs differs greatly from that of somatic cells, and a distinct feature is required to sustain the distinct properties of PSCs. To date, several studies have reported on the importance of metabolism in PSCs and their derivative cells. Here, we detail advancements in the field, with a focus on cardiac regenerative therapy.
多能干细胞（PSCs）在再生治疗、药物发现和疾病建模方面展现出了广阔的应用前景。虽然存在几种从PSCs分化出体细胞的方案，但它们的应用受到残留未分化PSCs污染和分化体细胞不成熟的限制。PSCs的代谢与体细胞有很大不同，维持PSCs独特特性需要一个独特的特征。迄今为止，已有多项研究报道了代谢在PSCs及其衍生细胞中的重要性。在此，我们详细阐述该领域的进展，重点关注心脏再生治疗。
