用于临床应用的多能干细胞代谢调控
Manipulation of Pluripotent Stem Cell Metabolism for Clinical Application.
作者信息
Tohyama Shugo, Tanosaki Sho, Someya Shota, Fujita Jun, Fukuda Keiichi
机构信息
Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo, 160-8582 Japan.
Department of Organ Fabrication, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo, 160-8582 Japan.
出版信息
Curr Stem Cell Rep. 2017;3(1):28-34. doi: 10.1007/s40778-017-0073-9. Epub 2017 Feb 13.
PURPOSE OF REVIEW
Pluripotent stem cells (PSCs) have the capacity to differentiate into various types of cells, and are promising cell sources for regenerative therapy and drug screening. However, to realize the clinical application of PSCs, a large number of highly qualified target cells must be stably prepared with low cost. To achieve this, great improvements in the reprogramming, differentiation, and elimination of residual PSCs will be necessary. In this review, we summarize the updated knowledge about metabolism in PSCs and its application.
RECENT FINDINGS
Recent studies have shown that PSCs have distinct metabolic profiles compared to differentiated cells. The metabolic profiles of PSCs are indispensable for the maintenance of pluripotency, self-renewal, differentiation capacity, and cell survival.
SUMMARY
Metabolic approaches show improved simplicity, scalability, and lower cost than conventional methods for differentiation and elimination of residual PSCs. Thus, manipulation of PSC metabolism will lead to new technologies to improve their efficiencies.
综述目的
多能干细胞（PSCs）具有分化为各种类型细胞的能力，是再生治疗和药物筛选中很有前景的细胞来源。然而，要实现PSCs的临床应用，必须以低成本稳定制备大量高质量的靶细胞。为实现这一目标，重编程、分化以及去除残留PSCs方面必须有重大改进。在本综述中，我们总结了关于PSCs代谢及其应用的最新知识。
最新发现
最近的研究表明，与分化细胞相比，PSCs具有独特的代谢特征。PSCs的代谢特征对于维持多能性、自我更新、分化能力和细胞存活是不可或缺的。
总结
与传统的分化和去除残留PSCs的方法相比，代谢方法具有更高的简便性、可扩展性和更低的成本。因此，对PSCs代谢的调控将带来提高其效率的新技术。
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