Department of Radiation Oncology, Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia.
Syst Rev. 2021 Feb 1;10(1):44. doi: 10.1186/s13643-021-01594-9.
In recent years, we have seen the incorporation of magnetic resonance imaging (MRI) simulators into radiotherapy centres and the emergence of the new technology of MR linacs. However, the significant health care resources associated with this advanced technology impact immediate widespread use and availability. There are currently limited studies to demonstrate the clinical effectiveness and inform decision-making on the use of MRI in radiotherapy. The objective of this scoping review is to identify and map the existing evidence surrounding the clinical implementation of MRI-guided radiotherapy in patients with breast cancer. It also aims to identify challenges and knowledge gaps in the literature.
We will perform a comprehensive search in MEDLINE and EMBASE databases from January 2010 onwards. Grey literature sources will include the WHO International Clinical Trials Registry Platform. We will include systematic reviews, randomised and non-randomised controlled studies published in English. Literature should examine the use of magnetic resonance imaging-guided radiotherapy in adults with breast cancer, regardless of cancer stage or severity. Two reviewers will independently screen all titles, abstracts and full-text reports. Data will be extracted and summarised using qualitative (e.g. content and thematic analysis) methods and presented in tables.
The results from this review will consolidate the evidence surrounding MRI-guided radiotherapy for breast cancer, contributing to the development and optimisation of patient selection, simulation, planning, treatment delivery, quality assurance and research, to help improve patient outcomes, cancer care and treatment for women with breast cancer.
The protocol is available on Open Science Framework at DOI https://doi.org/10.17605/OSF.IO/8TEV6.
近年来，我们看到磁共振成像（MRI）模拟器已被纳入放疗中心，新型的磁共振直线加速器技术也已出现。然而，这项先进技术需要大量的医疗保健资源，这对其即时广泛应用和普及造成了影响。目前，用于证明 MRI 在放疗中的临床有效性并为其使用提供决策信息的研究非常有限。本研究旨在通过对现有文献进行综述，确定和绘制围绕 MRI 引导放疗在乳腺癌患者中的临床应用的现有证据，并确定文献中的挑战和知识空白。
我们将对 2010 年 1 月以来 MEDLINE 和 EMBASE 数据库进行全面检索，同时对世界卫生组织国际临床试验注册平台等灰色文献来源进行检索。我们将纳入系统评价、随机和非随机对照研究，语言限定为英文。文献应检查 MRI 引导放疗在成人乳腺癌患者中的使用，无论癌症分期或严重程度如何。两名评审员将独立筛选所有标题、摘要和全文报告。使用定性方法（例如内容和主题分析）提取和总结数据，并以表格形式呈现。
该综述的结果将整合围绕 MRI 引导放疗治疗乳腺癌的证据，有助于制定和优化患者选择、模拟、计划、治疗实施、质量保证和研究，以帮助改善患者预后、癌症护理和乳腺癌患者的治疗效果。
本研究方案可在 Open Science Framework 上获取，网址为 DOI https://doi.org/10.17605/OSF.IO/8TEV6。
