Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Texas Christian University, University of North Texas Health Science Center School of Medicine, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.
Surg Pathol Clin. 2021 Mar;14(1):151-163. doi: 10.1016/j.path.2020.10.001. Epub 2021 Jan 5.
Salivary gland cancer is a heterogenous group of tumors that presents challenges with both diagnosis and therapy. Recent advances in the classification of salivary gland cancers have led to distinct histologic and genomic criteria that successfully differentiate between cancers with similar clinical behavior and appearance. Genomic abnormalities have led to the emergence of targeted therapies being used in their therapy with drastic improvements in outcomes as well as reductions in treatment-related toxicity. Dramatic results seen with molecular targets, such as HER2, TRK, and others, indicate that this approach has the potential to yield even better treatments for the future.
唾液腺癌是一组具有异质性的肿瘤，在诊断和治疗方面都存在挑战。近年来，唾液腺癌的分类取得了进展，形成了明确的组织学和基因组标准，成功地区分了具有相似临床行为和表现的癌症。基因组异常导致了靶向治疗的出现，这些治疗方法在改善治疗效果的同时，降低了治疗相关的毒性。HER2、TRK 和其他分子靶点的显著疗效表明，这种方法有可能为未来提供更好的治疗方法。
