Department of Pathology, UT Southwestern Medical Center, 6201 Harry Hines Boulevard, Dallas, TX 75390, USA.
Department of Pathology, Kaiser Permanente, 5601 De Soto Avenue, Woodland Hills, CA 91365, USA.
Surg Pathol Clin. 2021 Mar;14(1):17-24. doi: 10.1016/j.path.2020.09.004.
Sclerosing polycystic adenoma (SPA) is the more appropriate name for sclerosing polycystic adenosis. SPA is an uncommon salivary gland lesion with a constellation of unusual histologic findings that were originally interpreted as analogous to breast fibrocystic changes. The histologic findings in SPA include fibrosis, cystic alterations, apocrine metaplasia, and proliferations of ducts, acini, and myoepithelial cells in variable proportions. Because of its unusual mixed histology, SPA may be confused with a variety of lesions, ranging from reactive conditions to benign or even malignant neoplasms. The features of SPA are reviewed, with an emphasis on resolving its differential diagnosis.
硬化性多囊性腺瘤（SPA）是更适合的名称硬化性多囊性腺病。SPA 是一种不常见的唾液腺病变，具有一系列不寻常的组织学发现，最初被解释为类似于乳腺纤维囊性变化。SPA 的组织学发现包括纤维化、囊性改变、大汗腺化生以及导管、腺泡和肌上皮细胞的增生，比例各不相同。由于其不寻常的混合组织学，SPA 可能与各种病变混淆，从反应性病变到良性甚至恶性肿瘤。本文回顾了 SPA 的特征，并强调了解决 SPA 鉴别诊断的问题。
