• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

新发现的涎腺肿瘤的最新进展：分子和免疫组化结果及临床意义

Update of newly-recognized salivary gland neoplasms: molecular and immunohistochemical findings and clinical importance.

作者信息

Wolk Rachelle A, Cipriani Nicole A

机构信息

Oral and Maxillofacial Pathology, Radiology and Medicine, New York University College of Dentistry, New York, USA.

Department of Pathology, The University of Chicago, Chicago, IL, USA.

出版信息

Histopathology. 2025 Jan;86(2):183-198. doi: 10.1111/his.15289. Epub 2024 Aug 7.

DOI:10.1111/his.15289
PMID:39108216
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11649518/
Abstract

With the advancement of molecular testing and the routine use of immunohistochemical stains, salivary gland tumours previously categorized as adenoma or adenocarcinoma, not otherwise specified, are being reclassified with distinct diagnoses. Newly recognized benign entities include: sclerosing polycystic adenoma, keratocystoma, intercalated duct hyperplasia and adenoma, and striated duct adenoma. Newly recognized malignant salivary gland tumours include: microsecretory adenocarcinoma, sclerosing microcytic adenocarcinoma, and mucinous adenocarcinoma. Additionally, rare subtypes of mucoepidermoid carcinoma have been described, including Warthin-like and oncocytic. Understanding of intraductal carcinoma continues to evolve. Correctly distinguishing these lesions from mimickers can be crucial for appropriate patient care and prognostication, as well as future conceptualization of salivary disease.

摘要

随着分子检测技术的进步以及免疫组织化学染色的常规应用，先前归类为未另行特指的腺瘤或腺癌的涎腺肿瘤正被重新分类并给出明确诊断。新确认的良性实体包括：硬化性多囊性腺瘤、角化囊肿、闰管增生及腺瘤、纹管腺瘤。新确认的涎腺恶性肿瘤包括：微分泌腺癌、硬化性微细胞腺癌和黏液腺癌。此外，还描述了黏液表皮样癌的罕见亚型，包括沃辛瘤样和嗜酸性细胞型。对导管内癌的认识也在不断发展。正确地将这些病变与相似病变区分开来，对于恰当的患者治疗和预后评估，以及涎腺疾病的未来概念化可能至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/c2c6473234cc/HIS-86-183-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/23ca907af83b/HIS-86-183-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/7917d604ab8b/HIS-86-183-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/f720e382fecd/HIS-86-183-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/32f20d806de6/HIS-86-183-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/9dd4b26cde9b/HIS-86-183-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/e1fa0714bdd0/HIS-86-183-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/fb8f9722347f/HIS-86-183-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/adc9d8264f85/HIS-86-183-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/c2c6473234cc/HIS-86-183-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/23ca907af83b/HIS-86-183-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/7917d604ab8b/HIS-86-183-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/f720e382fecd/HIS-86-183-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/32f20d806de6/HIS-86-183-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/9dd4b26cde9b/HIS-86-183-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/e1fa0714bdd0/HIS-86-183-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/fb8f9722347f/HIS-86-183-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/adc9d8264f85/HIS-86-183-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e963/11649518/c2c6473234cc/HIS-86-183-g003.jpg

相似文献

1
Update of newly-recognized salivary gland neoplasms: molecular and immunohistochemical findings and clinical importance.新发现的涎腺肿瘤的最新进展：分子和免疫组化结果及临床意义
Histopathology. 2025 Jan;86(2):183-198. doi: 10.1111/his.15289. Epub 2024 Aug 7.
2
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.世界卫生组织头颈部肿瘤分类第 5 版更新：唾液腺。
Head Neck Pathol. 2022 Mar;16(1):40-53. doi: 10.1007/s12105-022-01420-1. Epub 2022 Mar 21.
3
Advances in salivary gland pathology.唾液腺病理学进展
Histopathology. 2007 Jul;51(1):1-20. doi: 10.1111/j.1365-2559.2007.02719.x. Epub 2007 May 31.
4
[Salivary gland tumors: 2022 WHO blue book and beyond].[唾液腺肿瘤：2022年世界卫生组织蓝皮书及其他]
Ann Pathol. 2024 May;44(3):175-182. doi: 10.1016/j.annpat.2024.02.005. Epub 2024 Mar 5.
5
Microsecretory adenocarcinoma: simplifying the diagnosis of a recently recognized salivary gland and cutaneous adnexal neoplasm.微分泌腺癌：简化一种新近认识的唾液腺和皮肤附属器肿瘤的诊断
Diagn Pathol. 2025 Apr 2;20(1):34. doi: 10.1186/s13000-025-01628-z.
6
Sclerosing Polycystic "Adenosis" of Salivary Glands: A Neoplasm Characterized by PI3K Pathway Alterations More Correctly Named Sclerosing Polycystic Adenoma.唾液腺硬化性多囊“腺瘤病”：一种以 PI3K 通路改变为特征的肿瘤，更名为硬化性多囊性腺瘤。
Head Neck Pathol. 2020 Sep;14(3):630-636. doi: 10.1007/s12105-019-01088-0. Epub 2019 Oct 11.
7
SOX10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: a clue to the histogenesis for tumor diagnosis.SOX10 是唾液腺肿瘤中腺泡和闰管分化的新型标志物：提示肿瘤发生的组织发生学有助于诊断。
Mod Pathol. 2013 Aug;26(8):1041-50. doi: 10.1038/modpathol.2013.54. Epub 2013 Apr 5.
8
LEF-1: Diagnostic utility in distinguishing basaloid neoplasms of the salivary gland.淋巴样增强因子-1：在鉴别涎腺基底样肿瘤中的诊断效用
Diagn Cytopathol. 2017 Dec;45(12):1078-1083. doi: 10.1002/dc.23820. Epub 2017 Oct 3.
9
Newly described salivary gland tumors.新描述的唾液腺肿瘤。
Mod Pathol. 2017 Jan;30(s1):S27-S43. doi: 10.1038/modpathol.2016.167.
10
Newly Described Entities in Salivary Gland Pathology.唾液腺病理学中的新描述实体
Am J Surg Pathol. 2017 Aug;41(8):e33-e47. doi: 10.1097/PAS.0000000000000883.

引用本文的文献

1
Mucoepidermoid Carcinoma Associated with an Intercalated Duct Lesion: Precursor or Coincidence?与闰管病变相关的黏液表皮样癌：是前驱病变还是巧合？
Head Neck Pathol. 2025 Mar 26;19(1):41. doi: 10.1007/s12105-025-01774-2.
2
Oncocytic Mucoepidermoid Carcinoma of the Parotid Gland.腮腺嗜酸性细胞黏液表皮样癌
Head Neck Pathol. 2025 Mar 15;19(1):30. doi: 10.1007/s12105-025-01768-0.

本文引用的文献

1
Molecular pathology in diagnosis and prognostication of head and neck tumors.头颈部肿瘤的诊断和预后中的分子病理学。
Virchows Arch. 2024 Feb;484(2):215-231. doi: 10.1007/s00428-023-03731-2. Epub 2024 Jan 13.
2
Keratocystoma: A Distinctive Salivary Gland Neoplasm Characterized by RUNX2 Rearrangements.角化囊肿：一种具有 RUNX2 重排特征的独特唾液腺肿瘤。
Am J Surg Pathol. 2024 Mar 1;48(3):317-328. doi: 10.1097/PAS.0000000000002169. Epub 2023 Dec 12.
3
Palisading Adenocarcinoma: A Morphologically Unique Salivary Gland Tumor With a Neuroendocrine-like Appearance and a Predilection for the Sublingual Glands of Women.
栅栏状腺癌：一种形态独特的唾液腺肿瘤，具有神经内分泌样外观，且好发于女性的舌下腺。
Am J Surg Pathol. 2023 Oct 1;47(10):1176-1185. doi: 10.1097/PAS.0000000000002091. Epub 2023 Jun 29.
4
NKX3.1 Expression and Molecular Characterization of Secretory Myoepithelial Carcinoma (SMCA): Advancing the Case for a Salivary Mucous Acinar Phenotype.NKX3.1 表达和分泌型肌上皮癌（SMCA）的分子特征：支持唾液黏液腺表型的观点。
Head Neck Pathol. 2023 Jun;17(2):467-478. doi: 10.1007/s12105-023-01524-2. Epub 2023 Feb 6.
5
Recurrent IDH2 Mutations in Salivary Gland Striated Duct Adenoma Define an Expanded Histologic Spectrum Distinct From Canalicular Adenoma.唾液腺纹状管腺瘤中复发性 IDH2 突变定义了一个与管状腺瘤不同的扩展组织学谱。
Am J Surg Pathol. 2023 Mar 1;47(3):333-343. doi: 10.1097/PAS.0000000000002004. Epub 2022 Dec 13.
6
A Subset of Salivary Intercalated Duct Lesions Harbors Recurrent CTNNB1 and HRAS Mutations: A Molecular Link to Basal Cell Adenoma and Epithelial-Myoepithelial Carcinoma?唾液腺闰管病变亚群存在 CTNNB1 和 HRAS 突变的反复发生：与基底细胞腺瘤和上皮-肌上皮癌的分子联系？
Head Neck Pathol. 2023 Jun;17(2):393-400. doi: 10.1007/s12105-022-01513-x. Epub 2022 Dec 8.
7
Microcribriform Adenocarcinoma of Salivary Glands: A Unique Tumor Entity Characterized by an SS18::ZBTB7A Fusion.涎腺微筛状腺癌：一种独特的肿瘤实体，其特征为 SS18::ZBTB7A 融合。
Am J Surg Pathol. 2023 Feb 1;47(2):194-201. doi: 10.1097/PAS.0000000000001980. Epub 2022 Oct 12.
8
Transformed microsecretory adenocarcinoma demonstrates high-grade morphology and aggressive biological behaviour.转化型微分泌腺癌表现出高级别形态学特征和侵袭性生物学行为。
Histopathology. 2022 Nov;81(5):685-688. doi: 10.1111/his.14777. Epub 2022 Aug 31.
9
NKX3.1 Expression in Salivary Gland "Intraductal" Papillary Mucinous Neoplasm: A Low-Grade Subtype of Salivary Gland Mucinous Adenocarcinoma.NKX3.1 在唾液腺“导管内”乳头状黏液性肿瘤中的表达：一种低级别唾液腺黏液性腺癌亚型。
Head Neck Pathol. 2022 Dec;16(4):1114-1123. doi: 10.1007/s12105-022-01471-4. Epub 2022 Jul 14.
10
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.世界卫生组织头颈部肿瘤分类第 5 版更新：唾液腺。
Head Neck Pathol. 2022 Mar;16(1):40-53. doi: 10.1007/s12105-022-01420-1. Epub 2022 Mar 21.