肌上皮癌。
Myoepithelial Carcinoma.
机构信息
Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
出版信息
Surg Pathol Clin. 2021 Mar;14(1):67-73. doi: 10.1016/j.path.2020.09.008. Epub 2021 Jan 5.
Abstract
Myoepithelial carcinoma (MECA) may overlap histologically with other salivary gland neoplasms, especially pleomorphic adenoma. MECA is characterized by cellular, uniform growth of myoepithelial cells and multinodular expansile invasive pattern with zonal cellular distribution. It may arise de novo or in association with pleomorphic adenoma (myoepithelial carcinoma ex pleomorphic adenoma). By immunohistochemistry, MECA is positive for cytokeratins and at least one of the myoepithelial markers, including S100. PLAG1 fusion is the most common genetic alteration. Carcinoma ex pleomorphic adenoma and necrosis correlate with worse clinical outcome in MECA, and necrosis can be used to stratify MECA as high grade.
摘要
肌上皮癌 (MECA) 在组织学上可能与其他涎腺肿瘤重叠，尤其是多形性腺瘤。MECA 的特征是肌上皮细胞的细胞均匀生长和多结节膨胀性浸润模式，具有区域性细胞分布。它可以是原发性的，也可以是与多形性腺瘤（肌上皮癌源自多形性腺瘤）相关的。通过免疫组织化学，MECA 对细胞角蛋白和至少一种肌上皮标志物呈阳性，包括 S100。PLAG1 融合是最常见的遗传改变。癌源自多形性腺瘤和坏死与 MECA 的临床预后较差相关，坏死可用于将 MECA 分层为高级别。
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2
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3
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