亚硝基涕灭威在体外诱导人淋巴细胞的姐妹染色单体交换。
Nitroso-aldicarb induces sister-chromatid exchanges in human lymphocytes in vitro.
作者信息
González Cid M G, Loria D, Matos E
机构信息
Instituto de Oncología Angel H. Roffo, Departamento de Investigaciones, Buenos Aires, Argentina.
出版信息
Mutat Res. 1988 Apr;204(4):665-8. doi: 10.1016/0165-1218(88)90070-5.
PMID:3352648
Abstract
Nitroso-aldicarb was tested for its ability to induce sister-chromatid exchanges (SCE) and cell-cycle delay in human peripheral blood lymphocytes in vitro. This derivative of aldicarb induced a dose-dependent increase in SCE values per cell. In addition, a slight decrease in the successive mitotic progression of cells in culture was observed.
摘要
对亚硝基涕灭威诱导人外周血淋巴细胞姐妹染色单体交换（SCE）及细胞周期延迟的能力进行了体外试验。涕灭威的这种衍生物可使每个细胞的SCE值呈剂量依赖性增加。此外，还观察到培养细胞连续有丝分裂进程略有减缓。
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