LPL AND ADRB2 GENE POLYMORPHISMS: RELATIONSHIP WITH LIPIDS AND OBESITY IN KAZAKH ADOLESCENTS.

The study is aimed at studying the relationship of polymorphisms of the ADRB2 (rs1042714) and LPL (rs328) genes with lipid changes and weight gain in adolescents of Kazakh nationality. A total of 184 Kazakh adolescents, aged 15 to 18, were included in the study. The main group included 70 overweight adolescents (BMI>23.5), and the control group included 114 adolescents with normal physique (BMI≤23.4). Single nucleotide polymorphisms rs1042714 [C/G] and rs328 [C/G] were determined by the TaqMan method, using for genotyping the DNA of peripheral blood cells. When comparing the polymorphisms rs1042714 of the ADRB2 gene (p=0.58) and rs328 of the LPL gene (p=0.12) with a body mass index, no relationship was found. The results of the study show that A1 hypoapolipoproteinemia was associated with the rs328 polymorphism of the LPL gene (p=0.002). rs1042714 of the ADRB2 gene is not associated with apoA1 groups (p=0.257). A comparison of body mass index (BMI) by gender showed that boys had a significantly higher BMI compared to girls (p=0.002). Between polymorphisms rs328 and rs1042714 did not reveal a statistically significant relationship with the risk of obesity among adolescents of Kazakh nationality. The rs328 polymorphism has an association with A1 hypoapolipoproteinemia in adolescents of Kazakh nationality. rs1042714 of the ADRB2 gene is not associated with a risk of A1hypoapolipoproteinemia.Low levels of apoA1 are more often accompanied by low levels of HDL (High-Density Lipoprotein) and high levels of insulin, insulin resistance index and apoB.