Dardari Dured, Dardari Randa
Department of Diabetes, Sud Francilien Hospital Center 40 Avenue Serge Dassault, Corbeil-Essonnes, France.
LEBPS, Univ Evry, IRBA, Université de Paris-Saclay, Evry, France.
Ann Transplant. 2021 Feb 2;26:e928449. doi: 10.12659/AOT.928449.
Charcot's neuroarthropathy is a destructive complication of the joint, which is often found in patients living with diabetes. Despite the fact that its description was published almost 100 years ago, its pathophysiology, diagnosis, and treatment remain areas that need to be updated. Its prevalence is low in patients living with diabetes, but this increases in particular situations such as peripheral neuropathy, as well as after simultaneous kidney-pancreas transplantation (SPKT) in patients living with type 1 diabetes. We suggest that the development of neuroarthropathy after SPK in not only due to glucocorticoid therapy, as described, but also to the rapid passage into euglycemia. The reduced prevalence of neuroarthropathy after only kidney transplantation compared to SPK seems to validate our hypothesis.
夏科氏关节病是一种关节的破坏性并发症，常见于糖尿病患者。尽管其描述早在近100年前就已发表，但其病理生理学、诊断和治疗仍有待更新。其在糖尿病患者中的患病率较低，但在诸如周围神经病变等特定情况下会增加，在1型糖尿病患者接受同期肾胰腺移植（SPKT）后也会增加。我们认为，SPK后神经关节病的发生不仅如所述是由于糖皮质激素治疗，还与快速进入血糖正常状态有关。与SPK相比，单纯肾移植后神经关节病患病率降低似乎证实了我们的假设。
