MedStar Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC, USA.
Curr Opin Organ Transplant. 2019 Aug;24(4):451-455. doi: 10.1097/MOT.0000000000000676.
To summarize the existing body of literature regarding quality of life after pancreas transplantation, discuss the limitations of existing studies and make an argument for the need for future investigation on this important topic using standard verifiable instruments and utility measurements.
Reinvigorating support for pancreas transplantation as a life-extending and quality-of-life-enhancing treatment for complicated diabetes mellitus remains a work in progress. Over the past two decades, improvements in surgical management, donor selection, recipient selection and immunosuppression have dramatically improved patient and graft outcomes, achieving durable restoration of normal glucose homeostasis in over 90% of patients. These significant advances in the field of pancreas transplantation have presumably had a positive effect on quality of life of pancreas recipients in the current era; however, this remains unconfirmed.
Technical success in pancreas transplantation has improved dramatically since quality of life was last vigorously investigated in pancreas transplant recipients. Comprehensive review of the literature demonstrates the need and potential usefulness of further study substantiating quality of life benefit after pancreas transplantation, as it remains one of the primary considerations for this procedure.
总结目前有关胰腺移植后生活质量的文献，讨论现有研究的局限性，并呼吁未来使用标准的可验证工具和效用测量方法对这一重要课题进行研究。
重新支持胰腺移植作为延长复杂糖尿病患者生命和提高生活质量的治疗方法仍在进行中。在过去的二十年中，手术管理、供体选择、受体选择和免疫抑制方面的改进极大地改善了患者和移植物的预后，使超过 90%的患者实现了持久的正常血糖稳态恢复。在胰腺移植领域的这些重大进展可能对当前时代胰腺受者的生活质量产生了积极影响；然而，这一点尚未得到证实。
自上次对胰腺移植受者的生活质量进行了深入研究以来，胰腺移植的技术成功率有了显著提高。对文献的综合回顾表明，有必要进一步研究证实胰腺移植后的生活质量获益，因为这仍然是该手术的主要考虑因素之一。
