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A WNT7B-mA-TCF7L2 positive feedback loop promotes gastric cancer progression and metastasis.

作者信息

Gao Qian, Yang Liuyang, Shen Aolin, Li Yang, Li Yongxiang, Hu Shilian, Yang Runhuai, Wang Xiangting, Yao Xuebiao, Shen Guodong

机构信息

Department of Geriatrics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.

Department of Genetics, School of Life Science, Anhui Medical University, Hefei, Anhui, 230032, China.

出版信息

Signal Transduct Target Ther. 2021 Feb 2;6(1):43. doi: 10.1038/s41392-020-00397-z.

DOI:10.1038/s41392-020-00397-z
PMID:33526767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7851143/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1776/7851143/15b32ef1d3e5/41392_2020_397_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1776/7851143/15b32ef1d3e5/41392_2020_397_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1776/7851143/15b32ef1d3e5/41392_2020_397_Fig1_HTML.jpg

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Gut. 2020 Jul;69(7):1193-1205. doi: 10.1136/gutjnl-2019-319639. Epub 2019 Oct 3.
3
Regulation of Gene Expression by N-methyladenosine in Cancer.
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Cell Commun Signal. 2024 Nov 11;22(1):538. doi: 10.1186/s12964-024-01892-4.
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A pan-cancer analysis of Wnt family member 7B in human cancers.人类癌症中Wnt家族成员7B的泛癌分析。
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Mol Med. 2024 Jul 25;30(1):108. doi: 10.1186/s10020-024-00878-9.
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