Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
J Antibiot (Tokyo). 2021 Apr;74(4):280-284. doi: 10.1038/s41429-020-00391-1. Epub 2021 Feb 1.
A fungal metabolite, isocladosporin was isolated from natural fungus, Cladosporium cladosporioides in the mid of 90s. Due to the lack of optical rotation of isolated natural product sample, the absolute configuration of the natural product remained undetermined for more than two decades. Herein, we demonstrated an SAR study of enantiomers of isocladosporin in herbicidal bio-assay against wheat coleoptile. Using this study as a comparative tool we further proposed the plausible absolute configuration of natural isocladosporin for the first time. The assigned configuration was also supported through biogenetic precursors.
真菌代谢产物异枝孢菌素于 20 世纪 90 年代中期从真菌枝孢属 Cladosporium cladosporioides 中分离得到。由于分离得到的天然产物样品没有旋光性，因此其绝对构型在二十多年的时间里一直没有确定。在这里，我们展示了异枝孢菌素对小麦胚芽鞘除草生物测定的对映异构体的构效关系研究。我们进一步首次使用这项研究作为比较工具，提出了天然异枝孢菌素可能的绝对构型。通过生物合成前体也支持了所分配的构型。
