Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, People's Republic of China.
College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Nat Prod Res. 2021 Apr;35(7):1115-1121. doi: 10.1080/14786419.2019.1641807. Epub 2019 Jul 15.
Cladosporine A (), a new indole diterpenoid alkaloid, was isolated from the extract of a fungal strain sp. JNU17DTH12-9-01. Its structure was elucidated by extensive spectroscopic analysis, and the absolute configurations were determined by electronic circular dichroism (ECD) experiments. This is the first report of the presence of indole diterpenoid alkaloid in the genus . The antimicrobial activities against 209P, ATCC0111, R330, and FIM709 were evaluated. Compound showed MICs of 4 μg/mL and 16 μg/mL against . 209P and . FIM709, respectively.
从真菌菌株 sp. JNU17DTH12-9-01 的提取物中分离得到一种新的吲哚二萜生物碱克拉多菌素 A ()。通过广泛的光谱分析阐明了其结构，并通过电子圆二色性 (ECD) 实验确定了其绝对构型。这是首次在 属中发现吲哚二萜生物碱。评估了对 209P、ATCC0111、R330 和 FIM709 的抗微生物活性。化合物 对 209P 和. FIM709 的 MIC 值分别为 4 μg/mL 和 16 μg/mL。
