Liu Di, Liang Yin-Hua, Yang Yun-Tao, He Miao, Cai Zi-Jun, Xiao Wen-Feng, Li Yu-Sheng
Department of Orthopedics, Xiangya Hospital of Central South University Xiangya Road 87, Changsha 410008, Hunan, P. R. China.
Department of Operating Room, Xiangya Hospital of Central South University Xiangya Road 87, Changsha 410008, Hunan, P. R. China.
Am J Transl Res. 2021 Jan 15;13(1):11-23. eCollection 2021.
Osteoarthritis (OA) is a common joint disease that mainly results in chronic pain, stiffness and dysfunction in elderly individuals. The molecular mechanisms in the pathogenesis of OA are still unclear, and available treatments are unable to slowdown the development of OA or reverse the tissue damage. Circular RNAs (circRNAs), a novel type of non-coding RNA, are ubiquitous, stable, evolutionally conserved, tissue-specific and functional. An increasing number of studies have revealed that many circRNAs are differentially expressed in OA-affected joint tissues and engage in the pathogenesis of OA by functioning as miRNA sponges. In this review, we briefly introduce the biogenesis, characteristics and functions of circRNAs, and shed light on the important role of circRNAs in the occurrence and progression of OA and their potential diagnostic and therapeutic value in this disease based on the research over the last five years.
骨关节炎（OA）是一种常见的关节疾病，主要导致老年人慢性疼痛、僵硬和功能障碍。OA发病机制中的分子机制仍不清楚，现有的治疗方法无法减缓OA的发展或逆转组织损伤。环状RNA（circRNAs）是一种新型的非编码RNA，具有普遍存在、稳定、进化保守、组织特异性和功能性等特点。越来越多的研究表明，许多circRNAs在受OA影响的关节组织中差异表达，并通过充当miRNA海绵发挥作用参与OA的发病机制。在本综述中，我们简要介绍了circRNAs的生物合成、特征和功能，并基于过去五年的研究，阐明了circRNAs在OA发生和发展中的重要作用及其在该疾病中的潜在诊断和治疗价值。
