使用生物信息学策略进行的系统分析确定SFTA1P和LINC00519为肺鳞状细胞癌潜在的预后生物标志物。
Systematic analysis using a bioinformatics strategy identifies SFTA1P and LINC00519 as potential prognostic biomarkers for lung squamous cell carcinoma.
作者信息
Yin Yu-Zhen, Yao Shi-Hua, Li Chun-Guang, Ma Yu-Shui, Kang Zhou-Jun, Zhang Jia-Jia, Jia Cheng-You, Hou Li-Kun, Qin Shan-Shan, Fan Xin, Zhang Han, Yang Meng-Die, Zhang Dan-Dan, Lu Gai-Xia, Wang Hui-Min, Gu Li-Peng, Tian Lin-Lin, Wang Pei-Yao, Cao Ping-Sheng, Wu Wei, Cao Zi-Yang, Lv Zhong-Wei, Shi Bo-Wen, Wu Chun-Yan, Jiang Geng-Xi, Fu Da, Yu Fei
机构信息
Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
Shanghai Clinical College, Anhui Medical University Hefei 230032, China.
出版信息
Am J Transl Res. 2021 Jan 15;13(1):168-182. eCollection 2021.
Abstract
Lung cancer has high incidence and mortality rates, in which lung squamous cell carcinoma (LUSC) is a primary type of non-small cell lung carcinoma (NSCLC). The aim of our study was to discover long non-coding RNAs (lncRNAs) associated with diagnose and prognosis for LUSC. RNA sequencing data obtained from LUSC samples were extracted from The Cancer Genome Atlas database (TCGA). Two prognosis-associated lncRNAs (including SFTA1P and LINC00519) were selected from LUSC samples, and the expression levels were also verified to be associated abnormal in LUSC clinical samples. Our findings demonstrate that lncRNAs SFTA1P and LINC00519 exert important functions in human LUSC and may serve as new targets for LUSC diagnosis and therapy.
摘要
肺癌具有较高的发病率和死亡率，其中肺鳞状细胞癌（LUSC）是一种主要的非小细胞肺癌（NSCLC）类型。我们研究的目的是发现与LUSC诊断和预后相关的长链非编码RNA（lncRNA）。从癌症基因组图谱数据库（TCGA）中提取了从LUSC样本获得的RNA测序数据。从LUSC样本中筛选出两个与预后相关的lncRNA（包括SFTA1P和LINC00519），并且其表达水平在LUSC临床样本中也被证实存在异常关联。我们的研究结果表明，lncRNAs SFTA1P和LINC00519在人类LUSC中发挥重要作用，可能成为LUSC诊断和治疗的新靶点。
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