关于 Valve 间质细胞信号传递：多尺度力学与机械生物学之间的联系。
On Valve Interstitial Cell Signaling: The Link Between Multiscale Mechanics and Mechanobiology.
机构信息
James T. Willerson Center for Cardiovascular Modeling and Simulation, The Oden Institute for Computational Engineering and Sciences and the Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA.
出版信息
Cardiovasc Eng Technol. 2021 Feb;12(1):15-27. doi: 10.1007/s13239-020-00509-4. Epub 2021 Feb 1.
Heart valves function in one of the most mechanically demanding environments in the body to ensure unidirectional blood flow. The resident valve interstitial cells respond to this mechanical environment and maintain the structure and integrity of the heart valve tissues to preserve homeostasis. While the mechanics of organ-tissue-cell heart valve function has progressed, the intracellular signaling network downstream of mechanical stimuli has not been fully elucidated. This has hindered efforts to both understand heart valve mechanobiology and rationally identify drug targets for treating valve disease. In the present work, we review the current literature on VIC mechanobiology and then propose mechanistic mathematical modeling of the mechanically-stimulated VIC signaling response to comprehend the coupling between VIC mechanobiology and valve mechanics.
心脏瓣膜在体内机械要求最高的环境之一中发挥作用，以确保单向血流。驻留的瓣膜间质细胞对这种机械环境做出反应，维持心脏瓣膜组织的结构和完整性，以维持体内平衡。虽然器官-组织-细胞心脏瓣膜功能的力学已经取得进展，但机械刺激下游的细胞内信号网络尚未完全阐明。这阻碍了人们理解心脏瓣膜机械生物学和合理确定治疗瓣膜疾病的药物靶点的努力。在本工作中，我们回顾了目前关于 VIC 机械生物学的文献，然后提出了机械刺激 VIC 信号反应的机械力学建模，以理解 VIC 机械生物学和瓣膜力学之间的耦合。
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