Anderson K J, Dam D, Lee S, Cotman C W
Department of Psychobiology, University of California, Irvine 92717.
Nature. 1988 Mar 24;332(6162):360-1. doi: 10.1038/332360a0.
Cutting the axons of the cholinergic neurons that project to the hippocampal formation results in death of most of these cells. Previous studies have shown that administration of nerve growth factor before or at the same time as the lesion will prevent this cell death. Here we demonstrate that basic fibroblast growth factor (FGF) administered into the brain reduces the death of cholinergic neurons in the medial septum and diagonal band of Broca after transection of their axons, in both young adult and aged rats. Moreover, FGF can partially protect against death of cholinergic neurons even when administered two days after axonal transection. These results indicate a possible function for FGF in the normal support of basal forebrain cholinergic neurons, but its range of activity could be wider, for FGF also supports noncholinergic neurons in vitro, it is localized in many of the central nervous system neurons, and it is found in relatively high concentrations in the brain.
切断投射至海马结构的胆碱能神经元的轴突会导致这些细胞中的大多数死亡。先前的研究表明，在损伤前或损伤时给予神经生长因子可防止这种细胞死亡。在此我们证明，向脑内注射碱性成纤维细胞生长因子（FGF）可减少成年和老年大鼠轴突横断后内侧隔核和布罗卡斜角带中胆碱能神经元的死亡。此外，即使在轴突横断两天后给予FGF，它也能部分保护胆碱能神经元免于死亡。这些结果表明FGF在正常支持基底前脑胆碱能神经元方面可能具有某种功能，但其活性范围可能更广，因为FGF在体外也能支持非胆碱能神经元，它定位于许多中枢神经系统神经元中，并且在脑中以相对较高的浓度存在。
