Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM UMR1291, CNRS UMR5051, University Toulouse III, Toulouse, France.
Pediatric Pneumo-allergology Department, Children's Hospital, University Hospital Centre of Toulouse, Toulouse, France.
Eur J Immunol. 2021 Mar;51(3):531-543. doi: 10.1002/eji.202048833. Epub 2021 Feb 17.
Food allergy is becoming a major public health issue, with no regulatory approved therapy to date. Food allergy symptoms range from skin rash and gastrointestinal symptoms to anaphylaxis, a potentially fatal systemic allergic shock reaction. IgE antibodies are thought to contribute importantly to key features of food allergy and anaphylaxis, and measurement of allergen-specific IgE is fundamental in diagnosing food allergy. This review will discuss recent advances in the regulation of IgE production and IgE repertoires in food allergy. We will describe the current understanding of the role of IgE and its high-affinity receptor FcεRI in food allergy and anaphylaxis, by reviewing insights gained from analyses of mouse models. Finally, we will review data derived from clinical studies of the effect of anti-IgE therapeutic monoclonal antibodies (mAbs) in food allergy, and recent insight on the efficiency and mechanisms through which these mAbs block IgE effector functions.
食物过敏正成为一个主要的公共卫生问题，迄今为止尚无经过监管部门批准的治疗方法。食物过敏的症状范围从皮疹和胃肠道症状到过敏反应（一种潜在致命的全身性过敏休克反应）。免疫球蛋白 E（IgE）抗体被认为对食物过敏和过敏反应的关键特征有重要贡献，过敏原特异性 IgE 的测量是诊断食物过敏的基础。这篇综述将讨论 IgE 产生和 IgE 库在食物过敏中的最新进展。我们将通过回顾从小鼠模型中获得的见解，描述当前对 IgE 及其高亲和力受体 FcεRI 在食物过敏和过敏反应中的作用的理解。最后，我们将综述来自抗 IgE 治疗性单克隆抗体（mAb）在食物过敏中的临床研究数据，以及最近关于这些 mAb 阻断 IgE 效应功能的效率和机制的见解。
