Department of Maternal Infantile and Urological Science, Sapienza University of Rome, 00161 Rome, Italy.
Independent Researcher, 00161 Rome, Italy.
Int J Mol Sci. 2024 Feb 27;25(5):2769. doi: 10.3390/ijms25052769.
Food allergy (FA) affects approximately 6-8% of children worldwide causing a significant impact on the quality of life of children and their families. In past years, the possible role of weaning in the development of FA has been studied. According to recent studies, this is still controversial and influenced by several factors, such as the type of food, the age at food introduction and family history. In this narrative review, we aimed to collect the most recent evidence about weaning and its role in FA development, organizing the gathered data based on both the type of study and the food. As shown in most of the studies included in this review, early food introduction did not show a potential protective role against FA development, and we conclude that further evidence is needed from future clinical trials.
食物过敏（FA）影响全球约 6-8%的儿童，对儿童及其家庭的生活质量造成重大影响。近年来，人们研究了断奶在 FA 发展中的可能作用。根据最近的研究，这仍然存在争议，并受多种因素影响，例如食物类型、引入食物的年龄和家族史。在这篇叙述性综述中，我们旨在收集关于断奶及其在 FA 发展中的作用的最新证据，根据研究类型和食物对收集到的数据进行组织。正如本综述中大多数研究所示，早期食物引入并没有显示出对 FA 发展的潜在保护作用，我们得出结论，需要未来的临床试验提供更多证据。
