Department of Dermatology, Manisa City Hospital, Manisa, Turkey.
Medical Faculty, Department of Dermatology, Manisa Celal Bayar University, Manisa, Turkey.
Dermatol Ther. 2021 Mar;34(2):e14835. doi: 10.1111/dth.14835. Epub 2021 Feb 11.
Hidradenitis suppurativa (HS) is a chronic, recurrent, and debilitating skin disease. Recent studies showed that inflammatory biomarkers, such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), Lymphocyte/HDL ratio (LHR), Neutrophil/HDL ratio (NHR), and Monocyte/HDL ratio (MHR) are an indicator of inflammatory diseases and may be associated with disease severity and disease activity. To investigate NLR, PLR, LHR, NHR, and MHR in HS patients. In addition, to compare erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), complete blood count, leukocyte profile, and biochemical parameters between the control and the patient group. Clinical and biochemical data of patients and healthy subjects were collected from medical records, retrospectively. In total, 166 patients with HS and 124 control subjects were included. We found no significant difference in NLR (P = .207) and PLR (P = .257). LHR (P < .001), NHR (P < .001), and MHR (P < .001) were significantly higher in the patient group. No positive correlation was found between any of these markers and disease severity according to Hurley staging system. However, MCV (Mean corpuscular volume), RDW (Red cell distribution width), and CRP showed a significant positive correlation with disease severity. Among these markers, only MHR was positively correlated with disease duration. Our study shows that CRP still maintains its value for HS patients compared to new inflammation markers. Unlike the studies in other inflammatory diseases, no significant relationship was found with most of these inflammatory parameters. MHR may be more useful in patients with HS as an indicator of inflammation compared to other parameters.
化脓性汗腺炎（HS）是一种慢性、复发性和使人虚弱的皮肤病。最近的研究表明，炎症生物标志物，如中性粒细胞-淋巴细胞比值（NLR）、血小板-淋巴细胞比值（PLR）、淋巴细胞/高密度脂蛋白比值（LHR）、中性粒细胞/高密度脂蛋白比值（NHR）和单核细胞/高密度脂蛋白比值（MHR）是炎症性疾病的指标，可能与疾病严重程度和疾病活动度有关。研究 HS 患者的 NLR、PLR、LHR、NHR 和 MHR。此外，比较对照组和患者组之间的红细胞沉降率（ESR）、C 反应蛋白（CRP）、全血细胞计数、白细胞谱和生化参数。从病历中回顾性地收集了患者和健康受试者的临床和生化数据。共纳入 166 例 HS 患者和 124 例对照组。我们发现 NLR（P =.207）和 PLR（P =.257）无显著差异。LHR（P <.001）、NHR（P <.001）和 MHR（P <.001）在患者组中显著升高。根据 Hurley 分期系统，这些标志物中没有一个与疾病严重程度呈正相关。然而，MCV（平均红细胞体积）、RDW（红细胞分布宽度）和 CRP 与疾病严重程度呈显著正相关。在这些标志物中，只有 MHR 与疾病持续时间呈正相关。我们的研究表明，与新的炎症标志物相比，CRP 对 HS 患者仍然具有价值。与其他炎症性疾病的研究不同，大多数炎症参数之间没有显著关系。与其他参数相比，MHR 可能是 HS 患者炎症的更有用指标。
