Shanxi Key Laboratory of Innovative Drugs for the, Treatment of Serious Diseases Based on Chronic Inflammation, College of Traditional Chinese Medicines, Shanxi University of Chinese Medicine, Taiyuan, Shanxi, 030619, P. R. China.
Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P. R. China.
ChemMedChem. 2021 May 18;16(10):1576-1592. doi: 10.1002/cmdc.202000996. Epub 2021 Mar 7.
Chronic inflammation represents a long-term reaction of the body's immune system to noxious stimuli. Such a sustained inflammatory response sometimes results in lasting damage to healthy tissues and organs. In fact, chronic inflammation is implicated in the development and progression of various diseases, including cardiovascular diseases, respiratory diseases, metabolic diseases, neurodegenerative diseases, and even cancers. Targeting nonresolving inflammation thus provides new opportunities for treating relevant diseases. In this review, we will go over several chronic inflammation-associated diseases first with emphasis on the role of inflammation in their pathogenesis. Then, we will summarize a number of natural products that exhibit therapeutic effects against those diseases by acting on different markers in the inflammatory response. We envision that natural products will remain a rich resource for the discovery of new drugs treating diseases associated with chronic inflammation.
慢性炎症代表了机体免疫系统对有害刺激的长期反应。这种持续的炎症反应有时会导致健康组织和器官的持久损伤。事实上，慢性炎症与多种疾病的发生和发展有关，包括心血管疾病、呼吸系统疾病、代谢性疾病、神经退行性疾病，甚至癌症。因此，针对未解决的炎症反应为治疗相关疾病提供了新的机会。在这篇综述中，我们首先将讨论几种与慢性炎症相关的疾病，重点介绍炎症在其发病机制中的作用。然后，我们将总结一些通过作用于炎症反应中的不同标志物来治疗这些疾病的天然产物。我们设想天然产物将继续成为发现治疗与慢性炎症相关疾病的新药的丰富资源。
