Dermatology Unit, Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich.
Department of Clinical Sciences, College of Veterinary Medicine, NC State University, Raleigh, NC 27607, USA.
Schweiz Arch Tierheilkd. 2021 Jan;163(1):67-72. doi: 10.17236/sat00287.
In this pilot study, we wished to determine if C-reactive protein (CRP) levels could be a useful severity or treatment biomarker for canine atopic dermatitis (AD). Nine atopic dogs received allergen immunotherapy for 1 year. Blood was collected before and at four re-evaluation visits. At each time point, the skin lesions were graded with the Canine Atopic Dermatitis Extent and Severity Index (CADESI) 4, and the plasma CRP levels were measured by Enzyme-linked Immunosorbent Assay (ELISA). We found a significant yet minimal correlation between the CRP levels and the CADESI4 scores. The CRP levels were not significantly different between dogs with AD of increasing severity. Finally, there was no correlation between the percentage change in CADESI4 and CRP values during immunotherapy. In conclusion, the lack of significant difference in CRP levels between dogs of increasing AD severity and lack of correlation between percentage changes in skin lesion and CRP values suggest that this protein would not be a clinically-useful biomarker in atopic dogs.
在这项初步研究中，我们希望确定 C 反应蛋白 (CRP) 水平是否可以作为犬特应性皮炎 (AD) 的严重程度或治疗的有用生物标志物。9 只特应性犬接受了为期 1 年的过敏原免疫治疗。在治疗前和 4 次重新评估时采集了血液。在每个时间点，使用犬特应性皮炎严重程度指数 (CADESI) 4 对皮肤病变进行评分，并通过酶联免疫吸附试验 (ELISA) 测量血浆 CRP 水平。我们发现 CRP 水平与 CADESI4 评分之间存在显著但最小的相关性。CRP 水平在病情逐渐加重的 AD 犬之间无显著差异。最后，在免疫治疗期间 CADESI4 和 CRP 值的百分比变化之间没有相关性。总之，病情逐渐加重的 AD 犬的 CRP 水平无显著差异，以及皮肤病变和 CRP 值的百分比变化之间无相关性表明，该蛋白在特应性犬中不是一种有用的临床生物标志物。
