Department of Animal Health Technology, Yamazaki University of Animal Health Technology, Tokyo, Japan (Mogi, Fukuyama); Hidamari Animal Hospital, Kanagawa, Japan (Yoshida); Tokyo Animal Allergy Center, Tokyo, Japan (Kawano); Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan (Arai).
Can Vet J. 2022 Apr;63(4):423-426.
We aimed to examine the effects of cannabidiol (CBD)-containing hemp oil without delta-9-tetrahydrocannabinol (THC) as a supplemental treatment for canine atopic dermatitis (CAD), as well as its adverse effects, and effects on concurrent drug use in dogs.
In this retrospective case series, 8 dogs with CAD were diagnosed by veterinary dermatologists certified by the Japanese Society of Veterinary Dermatology.
The medical records of dogs supplemented with CBD-containing hemp oil were evaluated with respect to signalment, physical examination, plasma C-reactive protein concentrations, pharmacologic management, the CAD Extent and Severity Index (4th iteration), and the Pruritus Visual Analog Scale.
Overall, CBD, used as a supplement in combination with other drugs, was well-tolerated over a wide dose range and decreased the occurrence of pruritus in dogs with CAD when ingested twice a day.
This study provides the first report of supplementation with CBD without THC that was effective in controlling pruritic behavior in dogs with CAD.
Further controlled studies are required to investigate the dose range, efficacy, and safety.
本研究旨在探讨不含Δ9-四氢大麻酚（THC）的大麻二酚（CBD） Hemp 油作为犬特应性皮炎（CAD）辅助治疗的效果、不良反应以及对同时使用的药物的影响。
在这项回顾性病例系列研究中，由日本兽医皮肤病学会认证的兽医皮肤科医生诊断了 8 只 CAD 犬。
评估了补充 CBD Hemp 油的犬的病历，包括品种、体格检查、血浆 C 反应蛋白浓度、药物管理、CAD 严重程度和严重程度指数（第 4 次迭代）和瘙痒视觉模拟量表。
总体而言，CBD 作为补充剂与其他药物联合使用时，在较宽的剂量范围内具有良好的耐受性，并且当每天摄入两次时，可减少 CAD 犬的瘙痒发生。
本研究首次报道了 CBD 补充剂可有效控制 CAD 犬的瘙痒行为，且不含有 THC。
需要进一步的对照研究来调查剂量范围、疗效和安全性。
