Weihe W, Manke A, Gowin W, Mariss G, Welter F L
Neurologische Klinik, Hardtwaldkliniken, Zwesten.
Nervenarzt. 1988 Jan;59(1):14-8.
175 patients with definite multiple sclerosis underwent nuclear magnetic resonance imaging. T1-weighted images showed in 59 patients (34%) periventricular lesions with a central area of decreased signal intensity. They appear as lacunar defects in the walls of the lateral ventricle system. In accordance with neuropathological findings we suggest that in these plaques a cystic degeneration has replaced gliosis. Patients with cystic defects are characterized by a high activity of the disease (e.d. increased annual production of plaques) and a poor prognosis. Lacunae are found in the early stages of the disease and provide a prognostic sign in multiple sclerosis.
175例确诊为多发性硬化症的患者接受了核磁共振成像检查。T1加权图像显示，59例患者（34%）出现脑室周围病变，病变中心信号强度降低。它们表现为侧脑室系统壁上的腔隙性缺损。根据神经病理学研究结果，我们认为在这些斑块中，囊性变取代了胶质增生。有囊性缺损的患者具有疾病活动度高（如每年新增斑块增多）和预后较差的特点。腔隙在疾病早期即可发现，是多发性硬化症的一种预后指标。
