磷脂酰胆碱对共济失调无效。

Lack of efficacy of phosphatidylcholine in ataxias.

作者信息

Sorbi S, Piacentini S, Marini P, De Scisciolo G, Amantini A, Amaducci L

机构信息

Department of Neurology, University of Florence, Italy.

出版信息

Neurology. 1988 Apr;38(4):649-50. doi: 10.1212/wnl.38.4.649.

DOI:10.1212/wnl.38.4.649

PMID:3352929

Abstract

We gave phosphatidylcholine orally at a daily dosage of 9 grams for 4 years to 20 subjects with Friedreich's ataxia (FA) and 24 with olivopontocerebellar atrophy (OPCA). There was no clinical improvement during the follow-up compared with 12 ataxic patients (six FA and six OPCA) who did not receive any treatment. A 6-month trial at a double dose did not have any significant effect. This study indicates that phosphatidylcholine does not change the natural course of ataxias.

摘要

我们对20例弗里德赖希共济失调（FA）患者和24例橄榄体脑桥小脑萎缩（OPCA）患者口服磷脂酰胆碱，每日剂量为9克，持续4年。与12例未接受任何治疗的共济失调患者（6例FA和6例OPCA）相比，随访期间未观察到临床改善。双倍剂量的6个月试验也没有任何显著效果。这项研究表明，磷脂酰胆碱不会改变共济失调的自然病程。