Chen Peng, Liu Bing, Wei Bo, Yu Shujuan
Department of Stomatology, The First Medical Center of PLA General Hospital Beijing, China.
Department of Stomatology, Air Force Medical Center Beijing, China.
Am J Cancer Res. 2022 Jul 15;12(7):3479-3485. eCollection 2022.
An odontogenic keratocyst (OKC) is a benign but aggressive intraosseous tumor derived from the remains of the original tooth germ or dental lamina. It has a marked ability to recur and become cancerous. However, patients with early-stage OKC often have no symptoms and manifestations. The common clinical manifestation is swelling. Hence, it is critical to precisely diagnose the disease, to use differential diagnosis in combination with auxiliary examination methods, and to select the most appropriate treatment option to reduce the loss of bone tissue and the related damage to patients. In recent years, with the advancement in understanding the molecular basis of this disease and the development of early detection and targeted therapy, the diagnosis and the prognosis of OKC have been improved. The aim of this study was to provide an overview on the clinical features, diagnosis, and treatment of OKC. The molecular and genetic basis of this disease and the characteristics of malignant transformation of OKC were also discussed. Finally, we presented patient cases from our clinical practice to provide some advice on the diagnosis and treatment of OKC.
牙源性角化囊肿（OKC）是一种源自原始牙胚或牙板残余的良性但具有侵袭性的骨内肿瘤。它具有显著的复发和癌变能力。然而，早期OKC患者通常没有症状和表现。常见的临床表现是肿胀。因此，精确诊断该疾病、结合辅助检查方法进行鉴别诊断以及选择最合适的治疗方案以减少骨组织损失和对患者的相关损害至关重要。近年来，随着对该疾病分子基础认识的进步以及早期检测和靶向治疗的发展，OKC的诊断和预后得到了改善。本研究的目的是概述OKC的临床特征、诊断和治疗。还讨论了该疾病的分子和遗传基础以及OKC恶变的特征。最后，我们展示了临床实践中的患者病例，为OKC的诊断和治疗提供一些建议。
