Clinical Pharmacy of the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, 510060, China; School of Clinical Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Clinical Pharmacy of the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, 510060, China.
Food Chem Toxicol. 2021 Mar;149:112032. doi: 10.1016/j.fct.2021.112032. Epub 2021 Jan 30.
Coreopsis tinctoria is commonly called Kunlun Chrysanthemum and a plateau plant with tremendous commercial value in functional tea and medicinal applications. In folk medicine, Kunlun Chrysanthemum flower is often used as an adjunctive therapy for diabetes and Alzheimer's disease. To further explore the chemicals responsible for the health benefits of Kunlun Chrysanthemum flowers, three homogeneous oligosaccharides, CT70-1A, CT70-1B and CT70-2 were isolated, and their detailed structures were determined from chemical and spectral analyses. The three oligosaccharides were composed of glucose, mannose, galactose, and arabinose in different ratios. They showed dose-dependent α-amylase and α-glucosidase inhibitory effects. In addition, they showed NO production inhibitory activities in BV2 cells, with IC values of 0.23, 0.24 and 0.27 mM, respectively. Taken together, these results suggested that Kunlun Chrysanthemum oligosaccharides might ameliorate hyperglycemia and neuroinflammation, which could prevent the development of diseases such as type 2 diabetes and Alzheimer's disease. This study provides chemical and bioactive perspectives that support the consumption of Kunlun Chrysanthemum flower tea for health benefits.
金鸡菊通常被称为昆仑菊，是一种高原植物，在功能茶和药用方面具有巨大的商业价值。在民间医学中，昆仑菊花常被用作糖尿病和老年痴呆症的辅助治疗。为了进一步探索昆仑菊花有益健康的化学成分，从化学和光谱分析中分离得到了三种均一的低聚糖 CT70-1A、CT70-1B 和 CT70-2，并确定了它们的详细结构。这三种低聚糖由不同比例的葡萄糖、甘露糖、半乳糖和阿拉伯糖组成。它们表现出剂量依赖性的α-淀粉酶和α-葡萄糖苷酶抑制作用。此外，它们在 BV2 细胞中表现出抑制 NO 产生的活性，IC 值分别为 0.23、0.24 和 0.27 mM。综上所述，这些结果表明，昆仑菊低聚糖可能改善高血糖和神经炎症，从而预防 2 型糖尿病和老年痴呆症等疾病的发展。本研究从化学和生物活性方面为饮用昆仑菊花茶有益健康提供了依据。
