Marine Biotechnology and Ecology Division, CSIR- Central Salt and Marine Chemicals Research Institute, G. B. Marg, Bhavnagar, Gujarat, 364002, India.
Marine Biotechnology and Ecology Division, CSIR- Central Salt and Marine Chemicals Research Institute, G. B. Marg, Bhavnagar, Gujarat, 364002, India.
Microbiol Res. 2021 May;246:126708. doi: 10.1016/j.micres.2021.126708. Epub 2021 Jan 22.
Actinobacteria are well-recognised biosynthetic factories that produce an extensive spectrum of secondary metabolites. Recent genomic insights seem to impact the exploitation of these metabolically versatile bacteria in several aspects. Notably, from the isolation of novel taxa to the discovery of new compounds, different approaches evolve at a steady pace. Here, we systematically discuss the enduring importance of Actinobacteria in the field of drug discovery, the current focus of isolation efforts targeting bioactive Actinobacteria from diverse sources, recent discoveries of novel compounds with different bioactivities, and the relative employment of different strategies in the search for novel compounds. Ultimately, we highlight notable progress that will have profound impacts on future quests for secondary metabolites of Actinobacteria.
放线菌是公认的生物合成工厂，能够产生广泛的次生代谢物。最近的基因组研究似乎在多个方面影响了这些代谢多样的细菌的开发利用。值得注意的是，从新型分类单元的分离到新化合物的发现，不同的方法都在稳步发展。在这里，我们系统地讨论了放线菌在药物发现领域的持久重要性，目前从各种来源分离具有生物活性的放线菌的重点，以及最近发现的具有不同生物活性的新型化合物，以及在寻找新型化合物时相对采用的不同策略。最终，我们强调了一些显著的进展，这些进展将对未来寻找放线菌次生代谢物产生深远的影响。
