生酮饮食在控制癫痫发作中的作用。
The role of ketogenic diet in controlling epileptic seizures.
机构信息
From the Pedartic Neurology, Neuroscience Center, King Fahad Specialist Hospital Dammam, Dammam, Kingdom of Saudi Arabia.
出版信息
Neurosciences (Riyadh). 2021 Jan;26(1):103-106. doi: 10.17712/nsj.2021.1.20200101.
OBJECTIVES
To study the role of the ketogenic diet (KD) in controlling seizures in children with medically resistant epilepsy in Saudi Arabia.
METHODS
This retrospective study was conducted in the Pediatric Neurology Clinic at a tertiary care epilepsy center. Thirty-one patients with medically resistant epilepsy were enrolled from 2013 to 2018. The seizure reduction variables were evaluated at 6, 12, 18 and 24 months after enrollment.
RESULTS
Of the 31 patients, 14 (45.2%) were males and 17 (54.8%) were females. The most common types of seizures were myoclonic seizures and mixed seizures, both of which occurred in 9 (29%) of the participants. Of the participants, 15 (48.4%) had seizures one to 5 times per day. Six months after starting a KD, 2 (6.45%) of participants were seizure-free; 6 (19.35%) were seizure-free after 12 months of treatment.
CONCLUSION
The present study highlighted the effectiveness of KD in medically resistant epilepsy children to local population. A larger cohort is warrant to confirm these findings.
目的
研究生酮饮食（KD）在控制沙特阿拉伯医学耐药性癫痫儿童癫痫发作中的作用。
方法
这是一项回顾性研究，在一家三级癫痫治疗中心的儿科神经病诊所进行。2013 年至 2018 年间，共纳入 31 名医学耐药性癫痫患者。在入组后 6、12、18 和 24 个月评估了癫痫发作减少的变量。
结果
31 名患者中，男性 14 名（45.2%），女性 17 名（54.8%）。最常见的癫痫发作类型是肌阵挛性发作和混合性发作，各有 9 名（29%）患者发生。15 名患者（48.4%）每天发作 1-5 次。开始 KD 治疗 6 个月后，2 名患者（6.45%）无癫痫发作；治疗 12 个月后，6 名患者（19.35%）无癫痫发作。
结论
本研究强调了 KD 在医学耐药性癫痫儿童中的有效性，适用于当地人群。需要更大的队列来证实这些发现。
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