Department of Stomatology, Wuchang Hospital of Wuhan.
Department of Stomatology, Wuchang Hospital Affiliated to Wuhan University of Science and Technology.
Medicine (Baltimore). 2021 Jan 29;100(4):e23755. doi: 10.1097/MD.0000000000023755.
Dental pain can have a detrimental effect on quality of life. Symptomatic apical periodontitis is the most common cause of dental pain and arise from an inflamed or necrotic dental pulp. There is growing evidence to support the effectiveness of probiotics in combination with antibiotics on periodontitis. We therefor will conduct this study to evaluate the clinical therapeutic effects of probiotics in combination with antibiotics on periodontitis.
We will systematically search the following databases: PubMed, the Cochrane Library, EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese BioMedical Literature Database (CBM), and WanFang database. A grey literature search will be conducted using ZETOC Conference Proceedings and Open Grey. Only randomized controlled trials (RCTs) related to research on probiotics in combination with antibiotics to treatment patients with periodontitis will be included. All sources have to be searched from their inception to October 2020. Two authors will independently select studies, extract study data, and evaluate the quality of the included studies. We will use Review Manager Software (RevMan 5.3) to analyze data.
This study will systematically evaluate the clinical therapeutic effects of probiotics in combination with antibiotics on periodontitis.
This study will generate evidence for a better clinical decision of patients with periodontitis.
DOI 10.17605/OSF.IO/QZ6SB (https://osf.io/qz6sb/).
牙痛会对生活质量产生不利影响。症状性根尖周炎是牙痛最常见的原因，由发炎或坏死的牙髓引起。越来越多的证据支持益生菌与抗生素联合治疗牙周炎的有效性。因此，我们将进行这项研究，以评估益生菌与抗生素联合治疗牙周炎的临床疗效。
我们将系统地搜索以下数据库：PubMed、Cochrane 图书馆、EMBASE、Web of Science、中国国家知识基础设施（CNKI）、中国生物医学文献数据库（CBM）和万方数据库。将通过 ZETOC 会议论文集和 Open Grey 进行灰色文献搜索。仅纳入关于益生菌与抗生素联合治疗牙周炎患者的研究的随机对照试验（RCT）。所有来源都必须从成立到 2020 年 10 月进行搜索。两名作者将独立选择研究、提取研究数据并评估纳入研究的质量。我们将使用 Review Manager 软件（RevMan 5.3）进行数据分析。
本研究将系统评估益生菌与抗生素联合治疗牙周炎的临床疗效。
本研究将为牙周炎患者的临床决策提供更好的证据。
DOI 10.17605/OSF.IO/QZ6SB（https://osf.io/qz6sb/）。
